Results 51 to 60 of about 428,606 (255)

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, EarlyView.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration

Advanced Science, EarlyView.
Schematic representation of contrast agent clearance by convective bulk flow from the ventricular spaces to the subarachnoid space on the ventral aspect of the brain, or by diffusion into the parenchyma across the pia‐glia or through the semi‐permeable ependyma. Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central
Yann Decker, Andreas Müller, Steven T. Proulx   +2 more
wiley   +1 more source

Intraoperative Fast Adaptive Focus Tracking Robotic OCT Enables Real‐Time Tumor Grading and Large‐Area Microvascular Imaging in Human Spinal Cord Surgery

Advanced Science, EarlyView.
The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He, Yuzhe Ying, Yejiong Shi, Zhe Meng, Zichen Yin, Zhengyu Chen, Zhangwei Hu, Ruizhi Xue, Linkai Jing, Yang Lu, Zhenxing Sun, Weitao Man, Youtu Wu, Dan Lei, Ning Zhang, Guihuai Wang, Ping Xue   +16 more
wiley   +1 more source

Diagnosis and treatment of adult medulloblastoma seeding in the intracranial-spinal subarachnoid space

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective To investigate the clinical diagnosis and treatment of adult medulloblastoma seeding in the intracranial-spinal subarachnoid space. Methods Eleven cases of adult medulloblastoma seeding in the intracranial-spinal subarachnoid space were ...
Ji-wei WANG, Bu-dong CHEN, Yu-shan YANG, Xin YAO   +3 more
doaj  

Reduced subarachnoid fluid diffusion in enlarged subarachnoid spaces of infancy

The Neuroradiology Journal, 2017
Background and purpose Enlargement of the subarachnoid spaces in infancy (ESSI) is a common cause of macrocephaly without proven explanation. We have observed subarachnoid diffusion to be decreased in these patients. We aim to quantify the diffusivity of ventricular and subarachnoid cerebrospinal fluid in ESSI patients, to determine if diffusion ...
Bonmyong Lee, Audrey McCarron, Gilbert Vezina, Gilbert Vezina, Matthew T Whitehead, Stanley T. Fricke, Stanley T. Fricke   +6 more
openaire   +4 more sources

Expanding the Phenotypic Spectrum of HNRNPU‐Related Disorder, Documenting the First Familial Presentation and Comprehensive Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HNRNPU‐related neurodevelopmental disorder (HNRNPU‐NDD) is caused by pathogenic and likely pathogenic variants in HNRNPU. With increasing accessibility to advanced genetic investigations, children presenting with developmental delay and intellectual disability will often undergo genomic testing; hence, the number of patients found to be ...
A. K. O. Hodgson, L. Baxandall, D. Aiyedun, A. Li, P. Y. B. Au, J. M. Bain, M. A. Gillentine, H. Goel, A. D. Kline, C. L. Ricupero, R. Sánchez‐Carpintero, E. P. Seward, R. Sidlow, S. A. Wilson, M. Balasubramanian   +14 more
wiley   +1 more source

Predicting the difficulty in performing a neuraxial blockade [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundTraumatic placement of a needle during a neuraxial blockade has been related to many complications such as postdural puncture headache, trauma to neural structures and even spinal hematoma, causing permanent neurologic deficits.
Jong Hae Kim, Seok Young Song, Baek Jin Kim   +2 more
doaj   +1 more source

Dual‐energy X‐ray absorptiometry for detecting neurogenic pulmonary edema in a mouse model of subarachnoid hemorrhage

Animal Models and Experimental Medicine, EarlyView.
Using a murine model of SAH, brain magnetic resonance imaging (MRI) was performed to confirm subarachnoid clot formation in the T2*‐weighted images sequence (left). Chest micro‐CT and DXA were performed to measure, respectively, the Hounsfield units (HU) and lean mass (LM) (middle) in order to test their relationship and ability to detect post‐SAH NPE (
Tatsushi Mutoh, Hiroaki Aono, Yushi Mutoh, Tatsuya Ishikawa   +3 more
wiley   +1 more source

Parenchymal Infiltration in Primary Diffuse Leptomeningeal Gliomatosis: Dynamic Changes in Brain MRI

Frontiers in Oncology, 2017
Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease with no special clinical manifestations. Here, we report the dynamic brain magnetic resonance imaging (MRI) changes in a 30-year-old female PDLG patient over a 10-month period.
Yun Jiang, Juan Chen, Jing He, Ao Pei, Jinsong Zhang, Yinhong Liu   +5 more
doaj   +1 more source

An Automatic Detection Method Of Cerebral Aneurysms In Time-Of-Flight Magnetic Resonance Angiography Images Based On Attention 3D U-Net [PDF]

arXiv, 2021
Background:Subarachnoid hemorrhage caused by ruptured cerebral aneurysm often leads to fatal consequences.However,if the aneurysm can be found and treated during asymptomatic periods,the probability of rupture can be greatly reduced.At present,time-of-flight magnetic resonance angiography is one of the most commonly used non-invasive screening ...
arxiv