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Automated Interpretation of Protein Subcellular Location Patterns

2006
Proteomics is a major current focus of biomedical research, and location proteomics is the important branch of proteomics that systematically studies the subcellular distributions for all proteins expressed in a given cell type. Fluorescence microscopy of labeled proteins is currently the main methodology to obtain location information.
Xiang, Chen, Robert F, Murphy
openaire   +2 more sources

Adaptation of Protein Surfaces to Subcellular Location

Journal of Molecular Biology, 1998
In vivo, proteins occur in widely different physio-chemical environments, and, from in vitro studies, we know that protein structure can be very sensitive to environment. However, theoretical studies of protein structure have tended to ignore this complexity.
Miguel Andrade   +2 more
exaly   +2 more sources

STIM1 regulates TRPC6 heteromultimerization and subcellular location

Biochemical Journal, 2014
STIM1 (stromal interaction molecule 1) regulates store-operated channels in the plasma membrane, but the regulation of TRPC (transient receptor potential canonical) heteromultimerization and location by STIM1 is poorly understood. STIM1 is a single transmembrane protein that communicates the filling state of the endoplasmic reticulum to store-operated ...
Letizia, Albarrán   +5 more
openaire   +2 more sources

Prediction of subcellular locations of proteins: Where to proceed?

PROTEOMICS, 2010
Abstract Since the proposal of the signal hypothesis on protein subcellular sorting, a number of computational analyses have been performed in this field. A typical example is the development of prediction algorithms for the subcellular localization sites of input protein sequences.
Kenichiro, Imai, Kenta, Nakai
openaire   +2 more sources

Subcellular location of crab poly(dA-dT)

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract The DNA isolated from the tissues of the marine crab Cancer borealis can be separated into a major and a minor component (satellite DNA), the latter being primarily an alternating sequence of deoxyadenylate-deoxythymidylate (poly(dA-dT)). The location of the poly(dA-dT) was investigated by purifying subcellular fractions of hepatopancreas ...
F A, Waldvogel, M N, Swartz
openaire   +2 more sources

Towards a better prediction of subcellular location of long non-coding RNA

Frontiers of Computer Science, 2022
Zhao-Yue Zhang   +3 more
semanticscholar   +1 more source

Improved Comparison of Protein Subcellular Location Patterns

3rd IEEE International Symposium on Biomedical Imaging: Macro to Nano, 2006., 2006
A common task in cell and molecular biology is to evaluate the difference or similarity among location patterns under different circumstances. Our previous work has described an automated method to objectively compare any pair of subcellular location patterns using well-characterized numerical features.
Ting Zhao, Stalia Soto, Robert F. Murphy
openaire   +1 more source

Subcellular location of lincomycin resistance in Nicotiana mutants

Molecular and General Genetics MGG, 1993
Lincomycin-resistant Nicotiana plumbaginifolia plastid mutants were considered also to carry mitochondrial mutations on the basis of their ability to grow in the dark under selective conditions. To clarify the role of mitochondria, individual protoplasts of the green, lincomycin-resistant N. plumbaginifolia mutant LR400 were microfused with protoplasts
A, Cséplö   +5 more
openaire   +2 more sources

The Subcellular Location of Antigens

1972
L. A. Wilson, D. B. Amos, W. Boyle
openaire   +1 more source

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