Results 171 to 180 of about 36,100 (249)

Serum Leptin Exacerbates Osteoarthritis by Promoting Subchondral Bone H‐Type Vessel Angiogenesis via Activation of the PI3K/AKT Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease closely associated with obesity. Adipokines secreted by adipose tissue play critical roles in disease progression. This study focuses on the adipokine leptin and investigates its relationship with knee osteoarthritis.
Ruifu Li, Zhao Xi, Shitong Luo, Jun Qin, Tao Liu, Jian Zhang   +5 more
wiley   +1 more source

Characterization of time-dependent changes in the subchondral bone density distribution of the proximal tibia following high tibial osteotomy. [PDF]

J Exp Orthop
Hosokawa Y, Iwasaki K, Ebata T, Sato D, Hamasaki M, Matsuoka M, Onodera T, Kondo E, Iwasaki N.   +8 more
europepmc   +1 more source

Retraction: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model

Journal of Anatomy, Volume 249, Issue 1, Page 114-126, July 2026.
Animals were sensitized with mBSA emulsified in CFA/IFA and subsequently received three intra‐articular injections of mBSA into either the TMJ or the knee (once per week). Mechanical hyperalgesia was assessed using electronic von Frey testing after arthritis establishment at 24 h or 7 days following the third intra‐articular injection.
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Delane Viana Gondim   +2 more
wiley   +1 more source

Mechanosensitive miRNAs in Cartilage and Subchondral Bone Remodeling: Emerging Targets for Osteoarthritis Therapy. [PDF]

J Inflamm Res
Shang X.
europepmc   +1 more source

A New Stage and Classification of Osteonecrosis of the Femoral Head Based on MRI With Pathophysiological Interpretation

Orthopaedic Surgery, Volume 18, Issue 7, Page 1448-1458, July 2026.
An MRI‐based classification system integrating fibrosis extent (F1–F3) and inflammatory bone marrow edema activity (E0–E3) was developed for osteonecrosis of the femoral head (ONFH). Increasing fibrosis and edema severity were associated with higher collapse risk, worse pain, and poorer hip function.
Mengran Shen, Hongxu Li, Haoyang Liu, Qihan Ma, Bailiang Wang, Liming Cheng, Jinhui Ma   +6 more
wiley   +1 more source

Retraction: Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Novel Biomaterial‐Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis‐Driven Osteoarthritis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
We successfully established a novel method for collecting synovial fluid in the murine knee joint using Tetra‐slime. Acute synovitis led to secondary cartilage degeneration in the early stage of OA, which might be attributed to the increase of MMP‐3, TNF‐α, and M1 macrophage activation in the synovium.
Kei Takahata, Kohei Arakawa, Takashi Yasuda, Saaya Enomoto, Takuya Katashima, Takamasa Sakai, Takanori Kokubun   +6 more
wiley   +1 more source

Humeral head in rotator cuff tear arthropathy shows reduced cartilage damage and uniform subchondral bone osteoporosis: a histomorphometric analysis. [PDF]

JSES Int
Maesako S, Tasaki T, Uekama K, Yokoyama S, Maeda S, Kitazono I, Taniguchi N, Tanimoto A.   +7 more
europepmc   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source