Results 91 to 100 of about 141,920 (285)

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

open access: yesAdvanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei   +10 more
wiley   +1 more source

Identifying and improving the fibre-degrading activity of rumen microbe-derived fibrolytic bacteria : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Manawatū, New Zealand [PDF]

open access: yes, 2017
The dairy industry is extremely important to the New Zealand (NZ) economy, and it accounts for approximately $16.6 billion in exports each year. In NZ, traditional feedstock for cattle, such as grass and hay, consists of cellulose-based fibrous material ...
Atua, Renée Mary Louise
core  

Justice in Many Rooms Since Galanter: De-Romanticizing Legal Pluralism Through the Cultural Defense [PDF]

open access: yes, 2008
Sharafi explores the emergence of legal pluralism during 1970s and 80s and discusses its relation in the cultural defense. Legal pluralism was more than a methodological stance intended to help lawyers and anthropologists talk to each other; it was an ...
Sharafi, Mitra
core   +3 more sources

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

open access: yesAdvanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang   +9 more
wiley   +1 more source

Girona: A Medieval City and the Modern Man, the Meeting

open access: yesИбероамериканские тетради
Girona is a Spanish city that has a long history. Its medieval spirit allows people to immerse themselves in the past and restore historical memory.
I. A. Malkovskaya
doaj   +1 more source

We’re So Bored With London, Wayne Daly in conversation with Russell Bestley, Parts 1 & 2 [PDF]

open access: yes, 2009
Interview discussion with Wayne Daly on the subject of UK punk ...
Bestley, Russ
core  

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

open access: yesAdvanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong   +11 more
wiley   +1 more source

The observance of the elements of the prison subculture among juvenile prisoners in the Republic of Moldova

open access: yesACROSS
This paper aims to determine the degree of compliance with the rules of the prison subculture among minors detained in the Republic of Moldova; to investigate the origins of the juvenile prison subculture and the factors contributing to its continued ...
Ludmila ŞUBELIC
doaj  

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

open access: yesAdvanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao   +19 more
wiley   +1 more source

What Implications Can Be Made From the Interactions Between Finances and Violations for Division 1 Men\u27s Basketball Schools? [PDF]

open access: yes, 2019
The purpose of this study was to find out what types of schools violated as well as the implications these violations had on internal finances. This research was practical and important because of it suggested possible motive for schools that want to ...
Burton, Michael
core   +1 more source

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