Results 61 to 70 of about 977,117 (291)
Alʹmanah Kliničeskoj Mediciny, 2019 Background: Methotrexate is the main synthetic disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other immunoinflammatory conditions.
D. E. Karateev +3 more
doaj +1 more source
Method for thermal monitoring subcutaneous tissue [PDF]
, 1985 A noninvasive accurate method for measuring the temperature of tissue beneath the surface of a living body is described. Ultrasonic signals are directed into beads of a material that are inserted into the tissue with a syringe.
Brandenburger, G. H., Heyman, J. S.
core +1 more source
Analysis of healthy sitting behavior: Interface pressure distribution and subcutaneous tissue oxygenation [PDF]
, 2009 Pressure ulcers are a large problem in individuals who use a wheelchair for their mobility and have limited trunk stability and motor function. Because no relation between interface pressure and pressure ulcer development has been established and no ...
Geffen, Paul van +5 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Percutaneous Wearable Biosensors: A Brief History and Systems Perspective
Advanced Sensor ResearchWearable biosensors are envisioned to disrupt both delivery and accessibility of healthcare by providing real‐time, continuous monitoring of informative and predictive physiological markers in convenient, user‐friendly, and portable designs.
Kaila L. Peterson +2 more
doaj +1 more source
Pharmaceutics, 2021 Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses.
Irin Tanaudommongkon +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Subcutaneous IgG Replacement Therapy by Push in 32 Patients with Primary Immunodeficiency Diseases in Argentine [PDF]
, 2014 Introduction: Regular replacement with immunoglobulin infusions is the mainstay of treatment in the majority of primary immunodeficiencies. Several studies showed that Subcutaneous Immunoglobulin (SCIG) has similar efficacy to Intravenous Immunoglobulin (
Bezrodnik, Liliana +6 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
An Unusual Presentation of Hydatid Disease in a Child: A Case Report
The Surgery Journal, 2021 The subcutaneous localization of the hydatid cyst in the abdominal wall is rarely encountered particularly in the pediatric population and is sometimes difficult to diagnose preoperatively.
Kamal El Haissoufi +3 more
doaj +1 more source