Results 91 to 100 of about 6,650,813 (243)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

The use of portable abdominal bioimpedance analyzer Yscope in the assessment of abdominal obesity

Roczniki Panstwowego Zakladu Higieny
Background Obesity, especially abdominal obesity, is strongly correlated with metabolic and other health risks. Diagnosis and assessment of obesity is important in clinical and routine preventive practice.
Martina Gažarová, Petra Lenártová, Monika Ondreičková, Laura Hačková   +3 more
doaj   +1 more source

Antiretoviral therapy and the lipodystrophy syndrome, part 2: Concepts in aetiopathogenesis [PDF]

, 2001
Clinical research has indicated that the use of nucleoside reverse transcriptase inhibitor (NRTI) and HIV protease inhibitor (PI) therapy is associated with a risk of long-term toxicity syndromes, and that the aetiopathogenesis of these adverse effects ...
Nolan, D., John, M., Mallal, S.
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Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Interobserver reproducibility of single-slice computed tomography for quantifying visceral and subcutaneous abdominal fat in obese adults

The Egyptian Journal of Radiology and Nuclear Medicine
Background Abdominal fat distribution plays a critical role in metabolic and surgical risk assessment. Although volumetric computed tomography (CT) is the gold standard for fat quantification, single-slice techniques are increasingly used in clinical ...
Islam Haney Shawali, Santosh Adhikari, Mohamed Elsayed Elshaaer, Rasha Mostafa Mohamed Ali   +3 more
doaj   +1 more source

Correlation of Liver Attenuation with Visceral Fat Area on Computed Tomography Scan: An Analytical Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: In the modern world, owing to rapid urbanisation and changes in lifestyles and dietary habits, obesity has emerged as a leading problem.
Tushar Kalekar, Aparna Prabhu, Nikith Soman, Ankita Pandey, Mudit Kumar, Deepu Palal   +5 more
doaj   +1 more source

Correlation of fat embolism severity and subcutaneous fatty tissue crushing and bone fractures [PDF]

, 2011
Pulmonary fat embolism (PFE) is frequently encountered in blunt trauma. The clinical manifestation ranges from no impairment in light cases to death due to right-sided heart failure or hypoxaemia in severe cases.
Thali, Michael Josef, Michael Josef Thali, Bolliger, Stephan, Stephan Andreas Bolliger, Garyfalia Ampanozi, Ampanozi, Garyfalia, Karin Muehlematter, Muehlematter, Karin   +7 more
core   +2 more sources

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Visceral-to-subcutaneous fat ratio as a predictor of the multiple metabolic risk factors for subjects with normal waist circumference in Korea

, 2017
Yun Hwan Oh,1,2 Ji Hyun Moon,1,2 Hyeon Ju Kim,1,3 Mi Hee Kong1,3 1Department of Family Medicine, Jeju National University Hospital, 2Department of Medicine, Graduate School of Jeju National University, 3Department of Family Medicine, School of ...
Kong MH, Moon JH, Kim HJ, Oh YH
core  

The Effect of a Reduced-Calorie Diet on alpha-2 Adrenergic Receptor Responsiveness in Abdominal Adipose Tissue in Obese Men During Exercise [PDF]

, 2008
There is at present an imperfect understanding of the effect of diet on availability of inhibitory receptors in fat cells during exercise among obese men. *Objective:* The purpose of this study was to determine whether diet results in
Roy R. Estrada, Joseph O. Schmelz, David Turbow, Edith Neumann   +3 more
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