Results 111 to 120 of about 6,650,813 (243)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

“MicroRNA Expression Profiling in human Subcutaneous Adipose Tissue” [PDF]

, 2008
MicroRNA are believed to be generally involved in more quantitative regulation of mammalian trait: therefore, mammalian conditions that have a strong genetic component and involve quantitative differences between the physiological and pathological ...
Castanò, Ilenia
core   +1 more source

Contrasting Cellularity and Fatty Acid Composition in Fat Depots from Alentejana and Barrosã Bovine Breeds Fed High and Low Forage Diets

International Journal of Biological Sciences, 2012
During the finishing phase of bovines, large amounts of subcutaneous and visceral fats are deposited leading to production inefficiencies with major impact on meat quality.
Ana S.H. Costa, Paula A. Lopes, Marta Estevão, Susana V. Martins, Susana P. Alves, Rui M.A. Pinto, Hugo Pissarra, Jorge J. Correia, Mário Pinho, Carlos M.G.A. Fontes, José A.M. Prates
doaj  

Abdominal fat depots and pancreatic volume in a 33 year old non-obese patient with type 2 diabetes, quantified from image obtained using MRI (1.5 Tesla) at L2/L3 region of lumbar vertebrae (A): Superficial abdominal subcutaneous fat, (B): Deep abdominal subcutaneous fat, (C): Anterior abdominal subcutaneous fat, (D): Posterior abdominal subcutaneous fat, (E): Intra-peritoneal fat, (F): Retroperitoneal fat & (G): Pancreatic volume.

, 2015
Abdominal fat depots and pancreatic volume in a 33 year old non-obese patient with type 2 diabetes, quantified from image obtained using MRI (1.5 Tesla) at L2/L3 region of lumbar vertebrae (A): Superficial abdominal subcutaneous fat, (B): Deep abdominal ...
Anoop Misra (289241), Seema Gulati (343833), Surya Prakash Bhatt (310846), Shajith Anoop (814482), Ravindra Mohan Pandey (814483), Kalaivani Mani (316531)   +5 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Comment on "Subcutaneous fat area at the upper thigh level is a useful prognostic marker in the elderly with femur fracture" by Kim et al. [PDF]

J Cachexia Sarcopenia Muscle, 2023
Kim YJ, Kim KW, Kim WY.
europepmc   +1 more source

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Association of <italic>AOC3</italic> Expression in Visceral Adipose Tissue and Circulating Soluble Vascular Adhesion Protein-1 with Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity

Obesity Facts
Introduction: Soluble vascular adhesion protein-1 (sVAP-1), which is identical to semicarbazide-sensitive amine oxidase (SSAO), contributes to oxidative stress and vascular dysfunction.
Osamu Horikawa, Maika Ikeda, Miwako Togawa, Yuta Koshikawa, Yasuhiro Watanabe, Yuka Takahashi, Taiki Nabekura, Daiji Nagayama, Kohji Shirai, Atsuhito Saiki   +9 more
doaj   +1 more source

Associations of subcutaneous fat area and Systemic Immune-inflammation Index with survival in patients with advanced gastric cancer receiving dual PD-1 and HER2 blockade. [PDF]

J Immunother Cancer, 2023
He M, Chen ZF, Zhang L, Gao X, Chong X, Li HS, Shen L, Ji J, Zhang X, Dong B, Li ZY, Lei T.   +11 more
europepmc   +1 more source