Results 121 to 130 of about 1,812,091 (361)

DOUBLE COSETS IN FREE PRODUCT

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2019
This paper deals with problems connecting with decomposition of groups into double cosets. It is established a relation between double decomposition and usual decomposition by subgroups for groups which can be decompose into a generalized free products ...
A.P. Goryushkin
doaj   +1 more source

Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

BMC Medical Research Methodology, 2016
BackgroundIt is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clinical trials, where conclusions for ...
J. Tanniou, I. van der Tweel, S. Teerenstra, K. Roes   +3 more
semanticscholar   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Three simple rules to ensure reasonably credible subgroup analyses

British medical journal, 2015
The limitations of subgroup analyses are well established—false positives due to multiple comparisons, false negatives due to inadequate power, and limited ability to inform individual treatment decisions because patients have multiple characteristics ...
J. Burke, J. Sussman, D. Kent, R. Hayward   +3 more
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Expressive subgroup signatures

, 2008
In this work, we propose a new generalization of the notion of group signatures, that allows signers to cover the entire spectrum from complete disclosure to complete anonymity.
Delerablée, Cécile, Boyen, Xavier, Cécile Delerablée, Xavier Boyen   +3 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Large normal subgroup growth and large characteristic subgroup growth [PDF]

, 2019
The maximal normal subgroup growth type of a finitely generated group is nlogn. Very little is known about groups with this type of growth. In particular, the following is a long standing problem: Let Γ be a group and Δ a subgroup of finite index ...
Barnea, Yiftach, Schlage-Puchta, J-C
core   +1 more source

Factors impacting the efficacy of venlafaxine extended release 75–225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan

Neuropsychiatric Disease and Treatment, 2018
Yoshinori Watanabe,1 Yuko Asami,2 Yoko Hirano,2 Kazuhiko Kuribayashi,3 Rio Itamura,4 Takayuki Imaeda4 1Himorogi Psychiatric Institute, Tokyo, Japan; 2Medical Affairs, Pfizer Essential Health, Pfizer Japan Inc., Tokyo, Japan; 3Clinical Statistics, Pfizer
Watanabe Y, Asami Y, Hirano Y, Kuribayashi K, Itamura R, Imaeda T   +5 more
doaj  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source