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Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Fresh-cut fruit salads (fruit cocktails) are marketed as a convenient food item with a limited shelf-life (4 days at 4 °C). Given rising electricity prices, increased cooling temperature during production, transport, and retail from 4 °C to 8 °C and ...
Beatrix W. Alsanius +2 more
doaj +1 more source
S2 Fig. Subject-by-subject comparison of models performance.
Surprise response as a probe for compressed memory states Levi-Aharoni H, Shriki O, Tishby N (2020) Surprise response as a probe for compressed memory states. PLOS Computational Biology 16(2): e1007065. Supplementary figure S2. (\textbf{
Hadar Levi-Aharoni (8455884)
core +1 more source
spine-generic/data-multi-subject: r20230223
What's Changed Add git annex init to download instructions by @mguaypaq in https://github.com/spine-generic/data-multi-subject/pull/114 Fix defaced images by @alexfoias in https://github.com/spine-generic/data-multi-subject/pull/119 add brain_t1 ...
Jan Valosek +13 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

