Results 101 to 110 of about 3,084 (245)

Agathis vs. Hymenaea-trapping biases to interpret arthropod assemblages in ambers. [PDF]

BMC Biol
Solórzano-Kraemer MM, Monleón-Getino A, Peñalver E, Kraemer AS, Herbert MCM, Peris D, Arillo A, Perrichot V, Barrón E, Garrouste R, Paulsen M, Delclòs X.   +11 more
europepmc   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Escaping the metric-driven governance trap in global health: how DALYs and coverage indicators mislead policymakers in LMICs. [PDF]

Int J Equity Health
Abdi YH, Bashir SG, Abdullahi YB, Adebisi YA, Lucero-Prisno DEI.   +4 more
europepmc   +1 more source

Typology of Creator Objections to Subject Cataloguing of Their Works

NASKO
The Library of Congress Subject Headings is a standardized system for indicating the topics of works held in the library. Since LCSH is built using literary warrant, based on the terminology and proportions of published works, it is appropriate to assess it according to how accurately its terms match the works it is applied to.
openaire   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Automated identification of MRI series using a hierarchical modular machine-learning pipeline. [PDF]

Eur Radiol Exp
Kujawa MJ, Fernández-Patón M, Cerdá Alberich L, Veiga-Canuto D, Martí-Bonmatí L.   +4 more
europepmc   +1 more source

Data saves lives: optimising routinely collected clinical data for rare disease research. [PDF]

Orphanet J Rare Dis, 2023
Solebo AL, Hysi P, Horvat-Gitsels LA, Rahi JS.   +3 more
europepmc   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Comprehensive dataset of Portuguese folk instruments for computer vision and heritage research. [PDF]

Data Brief
Silva Zendron LA, Sánchez San Blas H, Sales Mendes AF, Jiménez-Bravo DM, Lozano Murciego Á.   +4 more
europepmc   +1 more source