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Results 171 to 180 of about 3,251 (198)

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source

Regucalcin in the Tumor Microenvironment: From Intracellular Tumor Suppression to Putative Extracellular Signaling. [PDF]

Cancers (Basel)
Tominaga N.
europepmc +1 more source

Delimiting Species-Prospects and Challenges for DNA Barcoding. [PDF]

Mol Ecol
Emerson BC.
europepmc +1 more source

Rethinking planetary protection: an island biogeographical analysis. [PDF]

J R Soc Interface
Brener DJ, Cockell CS.
europepmc +1 more source

Identification of Splicing Variation Associated with Parental Behavior in the Burying Beetles (<i>Nicrophorus orbicollis</i>). [PDF]

J Genomics
Blythe VP, Min X, Panaitof SC.
europepmc +1 more source

Expanding HPV prevention across the life course: evidence on vaccine effectiveness in adults. [PDF]