Results 11 to 20 of about 3,092 (244)

Quo vadis Inhaltserschließung der Deutschen Nationalbibliothek? Herausforderungen und Perspektiven

o-bib. Das offene Bibliotheksjournal, 2015
Seit der Ausweitung des Pflichtexemplarrechts auf sog. unkörperliche Medienwerke im Jahr 2006 steht die Deutsche Nationalbibliothek (DNB) vor der Herausforderung, über neue Wege zur Erzeugung bibliografischer Metadaten nachzudenken.
Ulrike Junger
doaj   +1 more source

Sacherschließung unter FRBR und RDA in Theorie und Praxis

o-bib. Das offene Bibliotheksjournal, 2016
Zusammenfassung: Der Beitrag untersucht die Rolle der Sacherschließung in den "Functional Requirements for Bibliographic Records" (FRBR) und den damit verwandten Modellen (FRAD, FRSAD, FRBR-LRM) sowie im neuen Katalogisierungsstandard "Resource ...
Heidrun Wiesenmüller
doaj   +1 more source

International perspective and national reality in the Principi di Catalogazione e regole italiane di Diego Maltese

JLIS.it, 2019
The Paris Principles of 1961, resulting from a meeting between the leading librarians of the day, and the Florentine experience with the Bibliografia nazionale italiana (BNI), a site subject to international pressures and at the heart of Italian ...
Mauro Guerrini
doaj   +9 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Subject description of non-fiction literature for adults: expert-theoretical basis for the realisation of the »Hidden Treasure« research project

Knjižnica, 2004
Library users searching through non-fiction library material by subject in online OPACs, expect to be able to search fiction by subject as well. The research project Skriti zaklad (Hidden Treasure) was launched in 2002 and was aimed at improving the ...
Andrej Pogorelec, Alenka Šauperl, Milojka Miklavčič, Darja Šesek, Savina Zwitter   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cataloguing and Classification As Predictors of Library Use Among the Users of Public Universities in Kwara State

International Journal of Librarianship, 2023
This study investigates cataloguing and classification as a predictor of library use among users of libraries of public universities in Kwara State. Descriptive survey method is used for the population of users of libraries of Kwara State University ...
Abdulakeem S. Sulyman, Florence O. Ajani , Omolara B. Amzat , Bukola O. James   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source