Results 11 to 20 of about 3,251 (198)

Sacherschließung unter FRBR und RDA in Theorie und Praxis

open access: yeso-bib. Das offene Bibliotheksjournal, 2016
Zusammenfassung: Der Beitrag untersucht die Rolle der Sacherschließung in den "Functional Requirements for Bibliographic Records" (FRBR) und den damit verwandten Modellen (FRAD, FRSAD, FRBR-LRM) sowie im neuen Katalogisierungsstandard "Resource ...
Heidrun Wiesenmüller
doaj   +1 more source

International perspective and national reality in the Principi di Catalogazione e regole italiane di Diego Maltese

open access: yesJLIS.it, 2019
The Paris Principles of 1961, resulting from a meeting between the leading librarians of the day, and the Florentine experience with the Bibliografia nazionale italiana (BNI), a site subject to international pressures and at the heart of Italian ...
Mauro Guerrini
doaj   +9 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Subject description of non-fiction literature for adults: expert-theoretical basis for the realisation of the »Hidden Treasure« research project

open access: yesKnjižnica, 2004
Library users searching through non-fiction library material by subject in online OPACs, expect to be able to search fiction by subject as well. The research project Skriti zaklad (Hidden Treasure) was launched in 2002 and was aimed at improving the ...
Andrej Pogorelec   +4 more
doaj   +1 more source

Cataloguing and Classification As Predictors of Library Use Among the Users of Public Universities in Kwara State

open access: yesInternational Journal of Librarianship, 2023
This study investigates cataloguing and classification as a predictor of library use among users of libraries of public universities in Kwara State. Descriptive survey method is used for the population of users of libraries of Kwara State University ...
Abdulakeem S. Sulyman   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Automatic Subject Cataloguing at the German National Library

open access: yesLiber Quarterly: The Journal of European Research Libraries
The German National Library (DNB) began developing solutions for automatic subject cataloguing 15 years ago. The main reason for this was the huge and ever-growing number of digital media works that needed to be indexed.
Christoph Poley   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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