Results 161 to 170 of about 6,945,689 (299)

Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer. [PDF]

Signal Transduct Target Ther
Li X, Li MT, Ou KP, Gao PQ, Xiao AH, Yang J, Li JN, Deng WY, Bie MJ, Huang AL, Shi XF, Long QX.   +11 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Enhancing validation of case-control omics signatures through "minimalist" single-subject analysis (N-of-1 trials): proof of concept in sepsis. [PDF]

J Am Med Inform Assoc
Wilson LS, Pouladi N, Nelson RF, Middleton EA, Tolley ND, Shabanian M, Kenost C, Campbell RA, Rondina MT, Lussier YA.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Brain Architecture of Punishment Learning. [PDF]

J Neurosci
Gregory AV, Diefenbach J, Choi EA, Soo J, Chen J, Killcross AS, Jean-Richard-Dit-Bressel P, McNally GP.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Athletics--Indian Symbolism subject file

, 2010
Contains the contents of the "Athletics--Indian Symbolism" file from the University Archives Subject File Collection. This file primarily contains newspaper clippings as well as copies of pages from the College of William and Mary Colonial Echo yearbook,
The College of William and Mary
core  

Regional astrocyte dysregulation and altered glymphatic-related markers in Alzheimer's disease frontal cortex. [PDF]

Alzheimers Dement
Alexopoulos H, Louka XP, De Natale ER, Koutroubi K, Cashmore L, Panayotacopoulou MT, Trougakos IP, Wilson H, Politis M.   +8 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Exploring the Potential of Population-Optimized Red Blood Cell Antigens and Platelet HLA Typing for Homologous Blood Transfusion Detection in Japanese Athletes. [PDF]

Drug Test Anal
Momobayashi A, Okano M.
europepmc   +1 more source