Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Impact of visual mouth image presentation on speech perception in noise in normal hearing subjects and cochlear implant users. [PDF]
Schneider AM, Stöver T, Weissgerber T.
europepmc +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Twice as Sure?: Combining Biomarkers to Diagnose Rejection and Predict Kidney Allograft Survival. [PDF]
Ong SC, Mannon RB.
europepmc +1 more source
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
NLRP3 Inflammasome and Inflammation-Related Proteins Expression Characterized in Non-Cultivated Versus Cultivated Peripheral Blood Cells of Patients with Amyotrophic Lateral Sclerosis. [PDF]
Shevchuk D +5 more
europepmc +1 more source
Facial Emotion Recognition via Fusion of Deep and Handcrafted Features. [PDF]
Cha SE, Kwon B.
europepmc +1 more source
Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants. [PDF]
Khan MN, Poolos NP.
europepmc +1 more source
A meta-refined human Alzheimer's disease-associated gene subset shows partial mouse-model pathway correspondence and limited cross-cohort machine-learning transportability. [PDF]
Chai L +5 more
europepmc +1 more source

