Results 71 to 80 of about 2,964,574 (292)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Blind links, a big challenge in the linked data idea: Analysis of Persian Subject Headings

Iranian Journal of Information Processing & Management, 2014
In this survey, Linked data concept as exposing, sharing, and connecting pieces of data, information, and knowledge on the Semantic Web and some potential problems in converting Persian subject headings (PSHs) Records into linked data were discussed.
Atefeh Sharif
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The thematic structure of multidisciplinary license collections of periodicals: supply and demand

Библиосфера, 2017
The article analyses the subject structure of four large licensed journal collections of foreign publishers available for many Russian libraries due to the national subscription program financed by the Ministry of Education and Science of the Russian ...
N. N. Litvinova
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Birth of a Subject Heading

Library Resources & Technical Services, 2018
This paper illustrates the process by which a subject heading is created within the controlled vocabulary of the Library of Congress Subject Headings (LCSH). The author details the steps involved in proposing a subject heading for inclusion in the Subject Authority File at the Library of Congress using two case studies as examples, one in which the ...
openaire   +2 more sources

How to choose title and keywords for manuscript according to medical subject headings

Indian Journal of Vascular and Endovascular Surgery, 2018
Background: Title and keywords are the two most important parts of a manuscript. The words or phrases used in the title or keywords should be selected wisely for a wider dissemination of the article.
Himel Mondal, Shaikat Mondal, Sarika Mondal   +2 more
doaj   +1 more source

Mapping the biomedical sciences using Medical Subject Headings: a comparison between MeSH co-assignments and MeSH citation pairs. [PDF]

J Med Libr Assoc, 2021
Shu F, Qiu J, Larivière V.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source