Results 41 to 50 of about 205,338 (288)

A preliminary investigation of image indexing: the influence of domain knowledge, indexer experience and image characteristics [PDF]

, 2008
This study investigates the application of conceptual terms to images by individuals with various educational and occupational backgrounds. While the inherent complexities of applying terms to images are broadly acknowledged, few studies have addressed ...
Beaudoin, Joan E.
core   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Evolutionary Subject Tagging in the Humanities [PDF]

, 2011
Interdisciplinary research in the humanities requires indexing that represents multiple disciplinary perspectives. Most literature has been indexed using traditional models for subject analysis that are either too broad to be helpful or represent a ...
Daniel Benedetti, Garth Green, Jack Ammerman, Jack Ammerman, Vika Zafrin   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The non-unity of differential object marking

Isogloss
This paper shows that differential object marking (DOM) is not a unitary cross-linguistic phenomenon, and observes that its two subtypes, differential object flagging (DOF) and differential object indexing (DOI), probably have rather different ...
Martin Haspelmath
doaj   +1 more source

Indexação de obras de ficção em bibliotecas: avaliação e adequação do Modelo para Indexação de Ficção (MENTIF) [PDF]

, 2017
The Indexing of works of fiction to libraries catalogs requires an appropriate methodology linked to the textual structure of fiction narratives. The lack of an indexing methodology limits the representation and retrieval of subjects in the catalog.
Correia Bueno Degasperi, Márcia, Piovezan dos Santos, Luciana Beatriz, Rodrigues de Barros Ribas, Rosane, Sabbag, Deise Maria Antonio, Sampaio Rosas, Fábio, Spotti Lopes Fujita, Mariângela   +5 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Auditing scholarly journals published in Malaysia and assessing their visibility [PDF]

, 2012
The problem with the identification of Malaysian scholarly journals lies in the lack of a current and complete listing of journals published in Malaysia.
Edzan, N. N., Koh, A. P., Sanni, S. A., Zainab, A. N.   +3 more
core   +1 more source