Results 91 to 100 of about 169,367,286 (283)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Subject oriented approach to the study of higher spiritual capacities
RUDN Journal of Psychology and Pedagogics, 2010 Possibility of using subject oriented approach to the enquiry of spiritual capacities is reviewed; it is suggested holistic consideration of moral and intellectual parameters of subject's spiritual capacities in psychological study of deeds.
G V Ozhiganova
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
University Archives Subject File Collection
, 2012 Contents of the subject file as of 2/15/2012. From the file Dueling, University Archives Subject File Collection, Special Collections Research Center, Earl Gregg Swem Library, College of William and ...
College of William and Mary
core
The Role of Collection-Level Subject Metadata in Subject Access to Digital Collections in Aggregations [PDF]
, 2011 This paper presents a new area of research in library and information sciences - investigation into collection-level subject metadata that describes entire digital collections as integral wholes - and reports results of the multi-method exploratory study
Zavalina, Oksana
core
Numerical Study of Soil-Retaining Wall Behavior Subject to Machine Foundations Loads
Diyala Journal of Engineering SciencesA retaining wall was practically developed to provide lateral support for soil, and it is widely used in underground projects, highway barriers, and mines as well as for aesthetic considerations and slope stabilization.
Fatima M. Hassan, Waad A. Zakraia
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source