Results 101 to 110 of about 6,560,569 (228)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A STUDY ON THE LEARNING STRATEGIES USED IN TRANSLATION SUBJECT BY THE FIFTH SEMESTER STUDENTS OF ENGLISH DEPARTMENTAT UNIVERSITY OF MUHAMMADIYAH MALANG [PDF]

open access: yes, 2007
Learning translation is very important and useful at the present time. However, translating is not easy as it is imagined. To make the process of translation easy the translator needs some learning strategies.
INTAN PRAWESTI, ARDIANA
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Subject oriented approach to the study of higher spiritual capacities

open access: yesRUDN Journal of Psychology and Pedagogics, 2010
Possibility of using subject oriented approach to the enquiry of spiritual capacities is reviewed; it is suggested holistic consideration of moral and intellectual parameters of subject's spiritual capacities in psychological study of deeds.
G V Ozhiganova
doaj  

On the creation of a subject specific finite element model of the wrist joint [PDF]

open access: yes, 2007
Anatomy varies greatly between individuals and therefore it can be inaccurate to derive any clinical conclusions based on a single computer model. It is important to create models which are directly linked to a specific subject who then can be identified
BARNES, R., Gislason, M.K., Nash, D.H.
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Sugar beet growth research: All factors affecting growth of plants now subject to individual study in controlled environment laboratory

open access: yesCalifornia Agriculture, 1950
The investigations reported in the following article are being conducted through the cooperation of the California Institute of Technology, the Beet Sugar Development Foundation and the University of California College of Agriculture.
A Ulrich
doaj  

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