Results 141 to 150 of about 916,158 (354)
Professor's work: subjectivity,
Psicologia: Reflexão e Crítica, 2007 The article analyzes the effects of new work processes in a specific field: teaching and production in the academic context. To do so, it presents a brief history of capitalism, technology and work; analyzes the contemporary impacts of these processes in
Deise Mancebo
doaj
A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals
Advanced Science, EarlyView.Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu +8 more
wiley +1 more source
Advanced Science, EarlyView.In this study, an oxygen‐loaded and antimicrobial peptide (AP)‐functionalized scaffold (MBGAPO) is synthesized. With mesoporous structure of MBG applied as an “oxygen storage,” and AP‐provided antibacterial ability against E.coli and MRSA. MBGAPO exhibited osteogenic and multiplex‐immunomodulatory effects.
You Fu +7 more
wiley +1 more source
Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes
Advanced Science, EarlyView.Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He +6 more
wiley +1 more source
Advanced Science, EarlyView.A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying +6 more
wiley +1 more source
STEMDiff: A Wavelet‐Enhanced Diffusion Model for Physics‐Informed STEM Image Generation
Advanced Science, EarlyView.STEMDiff, which is a conditional diffusion model that generates realistic STEM images from crystal structure‐derived binary labels, is proposed, overcoming high‐frequency bias via a Discrete Wavelet Transform‐based architecture. It produces experimentally indistinguishable images, enabling annotation‐free training of networks for precise atomic ...
Yihui Bao +4 more
wiley +1 more source
Treating Hearing Loss: From Cochlear Implantation to Gene Therapy
Advanced Science, EarlyView.Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng +4 more
wiley +1 more source
MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu +23 more
wiley +1 more source