Results 91 to 100 of about 119,912 (302)

Efficacy and Safety of IncobotulinumtoxinA for Treatment of Sialorrhea: A Multicenter, Phase 3 Study in Japan

Movement Disorders Clinical Practice, EarlyView.
This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori, Yohei Mukai, Noriko Nishikawa, Kazuko Hasegawa, Masahiko Tomiyama, Yasuyoshi Kimura, Yoshio Tsuboi, Ryosuke Takahashi, Ryota Nakamura, Yuishin Izumi, Hirohisa Watanabe, Morinobu Seki, Kenji Sekiguchi, Shohei Tateishi, Yusaku Matsushita, Yusaku Nakamura   +15 more
wiley   +1 more source

Iguratimod alleviated Sjögren's syndrome through regulating macrophage polarization

Rheumatology &Autoimmunity, EarlyView.
Nonobese diabetic (NOD) mice exhibited characteristic of Sjögren's syndrome (SS), with increased M1 macrophages and deceased M2 macrophages. Iguratimod alleviated SS‐like symptoms and restored balance of macrophage polarization through inhibiting the mitogen‐activated protein kinases pathway in NOD mice.
Junqiao Guo, Yu Chen, Shumin Wang, Tingting Jiang, Yue Wang, Haolin Wu, Xiaojing Li, Genhong Yao   +7 more
wiley   +1 more source

IgG4- related disease: an orphan disease with many faces [PDF]

, 2014
Immunoglobulin G4- related disease (IgG4-RD) is a rare systemic fibro-inflammatory disorder (ORPHA284264). Although patients have been described more than 100 years ago, the systemic nature of this disease has been recognized in the 21(st) century only ...
Adelheid Wöhrer, Bastian Oppl, Herwig Pieringer, Ilse Parzer, Jochen Zwerina, Petra Reis   +5 more
core   +3 more sources

Insights into the molecular mechanism of Sjogren's syndrome [PDF]

, 2017
Sjogren’s syndrome (SS) is a chronic autoimmune disease, that affects primarily salivary and lacrimal glands, leading to increased morbidity. Recent studies indicate that loss of salivary gland function is associated with defective cell polarity ...
Langara, Hans A.
core  

Erarbeitung eines optimalen Aufnahmemodus zur dynamischen Bildgebung an einem Kleintier-Einzelphotonen-Emissionstomographie-Gerät und Etablierung von Normwerten bei der Nieren- und Speicheldrüsenfunktionsszintigraphie bei der Maus [PDF]

, 2019
Ziel: Ziel dieser Studien ist erstens die Ermittlung eines optimierten standardisierten Untersuchungsalgorithmus in der Multi-Pinhole Einzelphotonen-Emissionscomputertomographie (SPECT) für die dreidimensionale Nierenfunktions- und ...
Huang, Kai
core   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Generation of functional salivary gland tissue from human submandibular gland stem/progenitor cells

Stem Cell Research & Therapy, 2020
Background Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. However, the generated tissues are immature because the signaling factors that induce the differentiation of human ...
Yi Sui, Siqi Zhang, Yongliang Li, Xin Zhang, Waner Hu, Yanrui Feng, Jingwei Xiong, Yuanyuan Zhang, Shicheng Wei   +8 more
doaj   +1 more source

Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis

Rheumatology &Autoimmunity, EarlyView.
Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis. Abstract Both immunoglobulin (Ig) G4‐related disease (IgG4‐RD) and antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) are systemic disorders that affect a wide range of organs.
Wenhuan Zeng, Mingxin Bai, Yanying Liu
wiley   +1 more source

Parathyroid Hormone Sampling From the Anterior Jugular Vein Versus Peripheral Vein After Total Thyroidectomy

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background To determine if anterior jugular vein sampling (AJVS) is non‐inferior to peripheral venous sampling (PVS) for measuring intraoperative parathyroid hormone (PTH) levels following total thyroidectomy. Methods This was a prospective non‐inferiority trial conducted at a tertiary academic medical center.
Noel M. Phan, Keva Li, Eleni A. Varelas, Caleb J. Fan, Raymond L. Chai   +4 more
wiley   +1 more source

Post‐Therapeutic Dosimetry of Metastatic Castration‐Resistant Prostate Cancer With 177Lu‐PSMA: Experiences From Two University‐Based Hospitals in Thailand

Asia-Pacific Journal of Clinical Oncology, EarlyView.
ABSTRACT Objective 177Lu‐PSMA radioligand therapy (RLT) is increasingly used to treat metastatic castration‐resistant prostate cancer (mCRPC). Posttreatment dosimetry is essential for assessing normal organ absorbed doses. Therefore, this study aims to evaluate normal organs dosimetry in mCRPC patients undergoing 177Lu‐PSMA‐RLT from two university ...
Onnicha Pattanawong, Putthiporn Charoenphun, Wichana Chamroonrat, Thonnapong Thongpraparn, Nucharee Poon‐iad, Benjapa Khiewvan, Krisanat Chuamsaamarkkee   +6 more
wiley   +1 more source