Results 41 to 50 of about 10,107 (209)

A Novel Experimental Approach for In Vivo Analyses of the Salivary Gland Microvasculature

Frontiers in Immunology, 2021
Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies.
Bernd Uhl, Bernd Uhl, Constanze Braun, Julian Dominik, Joshua Luft, Martin Canis, Christoph A. Reichel, Christoph A. Reichel   +7 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Sialolithiasis and Poorly Controlled Type 2 Diabetes Mellitus

Journal of Dentistry Indonesia, 2015
Sialolithiasis is a common disease of the submandibular glands or its duct but rare in parotids of patients, especially in male adults. The accessory of salivary glands are small, unsheathed masses with a small canaliculi.
Agoeng Tjahjani Sarwono
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Clinical analysis of 21 cases of IgG4-related diseases

口腔疾病防治, 2022
Objective To summarize the clinical manifestations of IgG4-related diseases in the head and neck, explore treatment methods. Methods The clinical data of 21 patients diagnosed with IgG4-related diseases were retrospectively analyzed.
ZHANG Qi, NAN Xinrong, YAN Xingquan, ZHANG Zejun, ZHAO Jiaxiong, REN Xiaoyan   +5 more
doaj   +1 more source

Effect of Initial Treatment on Disease Outcome for Patients With Submandibular Gland Carcinoma [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2007
To elucidate the effect on outcome of initial surgical enucleation with or without definitive surgical resection and radiation therapy for patients with submandibular gland carcinoma.Retrospective clinicopathological review.Tertiary referral center.Eighty-seven consecutive patients (mean follow-up, 8.7 years) with primary submandibular gland carcinoma ...
Scott M, Kaszuba, Mark E, Zafereo, David I, Rosenthal, Adel K, El-Naggar, Randal S, Weber   +4 more
openaire   +2 more sources

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Enormous Asymptomatic Intraoral Sialolithiasis: A Case Report

Ear, Nose & Throat Journal
Sialolithiasis is one of the most common diseases of salivary glands. More than 80% of the sialoliths occur in the submandibular gland. While most of the calculi are less than 10 mm in size, 7.6% are larger than 15 mm and are classified as giant ...
Chia-Wei Liu MD, Wu-Chia Lo MD, PhD
doaj   +1 more source

Primary salivary acinar cell carcinoma of the parotid gland with parietal skull metastasis: A case report

Asian Journal of Surgery, 2022
Acinar cell carcinoma of the salivary gland (AciCC) is a rare low-grade epithelial malignant tumor of the salivary gland. The primary site of the disease is often in the parotid gland, followed by the submandibular gland and small salivary gland.
Yongkang Sun, Guangfu Di, Xiaochun Jiang
doaj   +1 more source