Results 51 to 60 of about 16,904 (241)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Oral Examination [PDF]

, 2017
The oral cavity is the first component of the digestive tract, which is delimited by the lips anteriorly and the oropharynx posteriorly. The oral cavity functions as a protective barrier and is an essential component for speech and swallowing ...
Burgess, Jeff, Eisen, Drore, Lynch, Denis P, Nordlund, James J., Stafford, Gary L, Villa, Alessandro, Wells, Michael J.   +6 more
core   +1 more source

Effect of thyroid statuses on sodium / iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice [PDF]

, 2010
Background Iodide that is essential for thyroid hormone synthesis is actively transported into the thyroid follicular cells via sodium/iodide symporter (NIS) protein in vertebrates.
Md. Harun-Or-Rashid, Masato Asai, Xiao-yang Sun, Yoshitaka Hayashi, Junichi Sakamoto, Yoshiharu Murata   +5 more
core   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Th17 cells play a critical role in the development of experimental Sjogren's syndrome [PDF]

, 2015
Objective Although Th17 cells have been increasingly recognised as an important effector in various autoimmune diseases, their function in the pathogenesis of Sjögren's syndrome (SS) remains largely uncharacterised.
Cao, X, Chan, VSF, Deng, J, Jiao, Z, Ko, KH, Lau, WCS, Lin, X, Lu, L, Rui, K, Tian, J, Wang, S, Wang, X   +11 more
core   +1 more source

Self-exfoliation of large submandibular stone-report of two cases

Contemporary Clinical Dentistry, 2012
Sialoliths are the most common diseases of the salivary glands. They may occur in any of the salivary gland ducts but are most common in Wharton′s duct and the submandibular gland.
Anita Singhal, Parul Singhal, Rangila Ram, Ranjan Gupta   +3 more
doaj   +1 more source

Clinical analysis of 21 cases of IgG4-related diseases

口腔疾病防治, 2022
Objective To summarize the clinical manifestations of IgG4-related diseases in the head and neck, explore treatment methods. Methods The clinical data of 21 patients diagnosed with IgG4-related diseases were retrospectively analyzed.
ZHANG Qi, NAN Xinrong, YAN Xingquan, ZHANG Zejun, ZHAO Jiaxiong, REN Xiaoyan   +5 more
doaj   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Sialolithiasis and Poorly Controlled Type 2 Diabetes Mellitus

Journal of Dentistry Indonesia, 2015
Sialolithiasis is a common disease of the submandibular glands or its duct but rare in parotids of patients, especially in male adults. The accessory of salivary glands are small, unsheathed masses with a small canaliculi.
Agoeng Tjahjani Sarwono
doaj   +1 more source

Primary salivary acinar cell carcinoma of the parotid gland with parietal skull metastasis: A case report

Asian Journal of Surgery, 2022
Acinar cell carcinoma of the salivary gland (AciCC) is a rare low-grade epithelial malignant tumor of the salivary gland. The primary site of the disease is often in the parotid gland, followed by the submandibular gland and small salivary gland.
Yongkang Sun, Guangfu Di, Xiaochun Jiang
doaj   +1 more source