Results 41 to 50 of about 212,791 (331)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Research on intelligent predicting method of underwater acoustic field based on physics-informed neural network

Frontiers in Marine Science
In the context of the rapid development of computer hardware and the continuous improvement of the artificial intelligence and deep learning theory, aiming at the traditional numerical solution method to solve the underwater acoustic fluctuation equation
Lei Chen, Lin Zhang, Xuehai Sun, Xuehai Sun, Jiaxi Duan, Lijun Yin, Xinshuo Zheng, Jie Chen   +7 more
doaj   +1 more source

Tidal oscillations at the head of Monterey Submarine Canyon and their relation to oceanographic sampling and the circulation of water in Monterey Bay. Annual report, Part 6, September 1972 [PDF]

, 1972
During a 25-hour hydrographic times series at two stations near the head of Monterey Submarine Canyon, an internal tide was observed with an amplitude of 80 to 115 m in water depths of 120 and 220 m respectively.
Broenkow, William W., McKain, Scott J.
core  

Meltwater Intrusions Reveal Mechanisms for Rapid Submarine Melt at a Tidewater Glacier [PDF]

, 2019
Submarine melting has been implicated as a driver of glacier retreat and sea level rise, but to date melting has been difficult to observe and quantify. As a result, melt rates have been estimated from parameterizations that are largely unconstrained by ...
Amundson, Jason M., Jackson, R. H., Kienholtz, C., Motyka, R. J., Nash, J. D., Pettit, E. C., Skyllingstad, E., Sutherland, D. A., Winters, D.   +8 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A Novel Method for Estimating the State of Charge of Lithium Batteries Adopts a Bidirectional Gated Recurrent Unit With Attention Mechanism and Piecewise Estimation

IEEE Access
Accurate estimation of the state of charge (SOC) in lithium-ion batteries is fundamental to ensuring their safe and reliable operation. however, the influence of factors such as battery state, discharge conditions, and environmental temperature poses ...
Weida Cheng, Shuo Sun, Hang Yin, Zongliang Wang, Wei Cai   +4 more
doaj   +1 more source

Sea-floor tectonics and submarine hydrothermal systems [PDF]

, 2005
The discovery of metal-depositing hot springs on the sea floor, and especially their link to chemosynthetic life, was among the most compelling and significant scientific advances of the twentieth century. More than 300 sites of hydrothermal activity and
de Ronde, Cornell D. J., Hannington, Mark D., Petersen, Sven   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

RV Pelagia Cruise 64PE372, 27 Jun - 11 Jul 2013. Flow dynamics and sedimentation in an active submarine channel: a process-product approach [PDF]

, 2014
Novel technologies are providing new opportunities to study the structure and dynamics of submarine sediment-gravity flows; these flows are the dominant process for transfer of sediment into the deep ocean, but are very hard to monitor due their ...
et al,, Wynn, R.B.
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source