Results 121 to 130 of about 11,989 (309)

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Identification and analysis of interactions between sea use functions [PDF]

This report focuses on the interactions both positive and negative between offshore wind energy and the non-wind sea use functions.Some sea use functions can co-exist without substantial negative effects.
Jongbloed, R.H., Leopold, M.F., Quirijns, F.J., Slijkerman, D.M.E., Wal, J.T., van der   +4 more
core   +1 more source

Illusion of Power: Russia after the South Caucasus Battle. CEPS Working Document No. 311, 24 February 2009 [PDF]

, 2009
The war in the South Caucasus sent shockwaves throughout the post-Soviet world, European capitals and across the Atlantic, making more urgent the demand for a re-evaluation of policies towards Russia.
Secrieru, Stanislav.
core  

An Analytical Method for Mechanical Analysis of Offshore Pipelines during Lifting Operation. [PDF]

Materials (Basel), 2023
Wang Z, Chen Y, Gao Q, Li F.
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Ocean Governance [PDF]

, 2014
There are a range of legal instruments, institutions, and organizations that collectively establish rules and policies for managing, conserving, and using the ocean.

core  

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

A novel strategy for fast liquefaction detection around marine pipelines: a finite element-machine learning approach

Frontiers in Marine Science
With the increasing global exploration of marine resources, ensuring the stability of submarine pipelines under adverse conditions—such as strong ocean waves and seismic events—remains a significant challenge.
Xing Du, Xing Du, Yongfu Sun, Yupeng Song, Wanqing Chi, Zongxiang Xiu, Xiaolong Zhao, Dong Wang   +7 more
doaj   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Freedom of Navigation in a Post-UNCLOS III Environment [PDF]

, 1983
Clingan, Thomas A., Jr.
core   +2 more sources