Results 141 to 150 of about 11,989 (309)

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

open access: yesAdvanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu   +9 more
wiley   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

open access: yesAdvanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju   +5 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

open access: yesAdvanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li   +15 more
wiley   +1 more source

High-fidelity simulations of the lobe-and-cleft structures and the deposition map in particle-driven gravity currents [PDF]

open access: yes, 2015
J. H. Silvestrini   +5 more
core   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

open access: yesAdvanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng   +18 more
wiley   +1 more source

Technology transfer from the Hawaii Deep Water Cable Program [PDF]

open access: yes, 1987
"The Hawaii Deep Water Cable Program (HDWCP) is a research and development effort to determine the feasibility of installing and operating a submarine power transmission system between the Islands of Hawaii and Oahu in the Hawaiian Archipelago.

core  

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen   +13 more
wiley   +1 more source

Damage Analysis of Submarine Pipelines with Corrosion Defects Under Impact Load

open access: yesShiyou jixie
Considering that submarine oil and gas pipelines are susceptible to damage and destruction caused by impact and corrosion,based on the Coupled Euler-Lagrange(CEL)algorithm,a finite element model of falling object-corroded pipeline-seabed soil impact was ...
Ren Tao   +3 more
doaj  

Investigation on the Effects of Uncertainties in Construction Quality on the Bursting Capacity of Submarine Pipelines

open access: yesInternational Journal of Coastal and Offshore Engineering, 2017
Construction quality plays an important role in the integrity of submarine oil and gas pipelines during their lifetime. Quality of material and quality of construction contractors are two major contributors to the durability of the pipelines.
Bahram Mehrafrooz   +2 more
doaj  

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