Results 181 to 190 of about 47,020 (301)

Catatonia and elevated mortality: A population‐wide cohort study with healthy, sibling, and schizophrenia spectrum controls

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Aim To determine whether catatonia is associated with increased long‐term all‐cause and cause‐specific mortality. Methods Using Taiwan's National Health Insurance Database (2000–2022), we assembled a population‐based cohort of all adults (≥18 years) with catatonia and matched each to four controls without catatonia on sex and birthdate.
Chih‐Wei Hsu   +7 more
wiley   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang   +3 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda   +4 more
wiley   +1 more source

AI Alignment Versus AI Ethical Treatment: 10 Challenges

open access: yesAnalytic Philosophy, EarlyView.
ABSTRACT A morally acceptable course of AI development should avoid two dangers: creating unaligned AI systems that pose a threat to humanity and mistreating AI systems that merit moral consideration in their own right. This paper argues these two dangers interact and that if we create AI systems that merit moral consideration, simultaneously avoiding ...
Adam Bradley, Bradford Saad
wiley   +1 more source

How do physiological networks respond to normobaric hypoxia and isometric exercise?

open access: yesExperimental Physiology, EarlyView.
Abstract The dynamics of physiological systems are impacted by both exercise and hypoxia. Network models can be used to map the interactions between various physiological components in environmental physiology and exercise using the concepts of information theory.
Danilo Bondi   +6 more
wiley   +1 more source

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima   +9 more
wiley   +1 more source

Restoring decision‐making capacity through ECT to enable clozapine initiation in treatment‐resistant schizophrenia: An ethical and clinical case report

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Background Treatment‐resistant schizophrenia (TRS) is often accompanied by poor insight and impaired decision‐making capacity (DMC), complicating the initiation of clozapine (CLZ) despite clear clinical indications. In Japan, CLZ utilization is markedly lower than in many foreign countries, partly due to concerns about adverse effects ...
Shimpei Hanaoka   +2 more
wiley   +1 more source

Short‐term outcome of substance‐induced psychotic disorder in a large UK first episode psychosis cohort [PDF]

open access: bronze, 2016
Andrew Thompson   +11 more
openalex   +1 more source

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