Results 131 to 140 of about 1,257,231 (376)

O primeiro contato com as drogas: análise do prontuário de mulheres atendidas em um serviço especializado

open access: yesSaúde em Debate
O estudo objetivou caracterizar e compreender o contexto em que se dá o primeiro contato de mulheres com problemas relacionados ao uso de substâncias psicoativas que procuraram atendimento em um serviço especializado em álcool e outras drogas.
Divane de Vargas   +4 more
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

How to face a patient with benzodiazepine dependence in primary health care? Strategies for withdrawal

open access: yesMedwave, 2018
Resumen Las benzodiacepinas son fármacos ampliamente utilizados en atención primaria de salud. Su uso prolongado se ha convertido en un problema relevante dadas las consecuencias médicas que ocasionan, especialmente en adultos mayores.
Josefina Aguiluz   +4 more
doaj   +1 more source

Topiramate in the treatment of substance-related disorders: a critical review of the literature.

open access: yesJournal of Clinical Psychiatry, 2010
OBJECTIVE To critically review the literature on topiramate in the treatment of substance-related disorders. DATA SOURCES A PubMed search of human studies published in English through January 2009 was conducted using the following search terms ...
Ann K. Shinn, S. Greenfield
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Age and its Effect on Drug Addiction Treatment [PDF]

open access: yes, 2023
Substance use disorders and addiction have become increasingly serious problems in the United States. Diseases of this nature revolve around problematic patterns of substance use and abuse of alcohol, illicit drugs, prescription drugs, and over-the ...
Haberman, Skylar
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Scaling behavior of the disordered contact process [PDF]

open access: yesarXiv, 2008
The one-dimensional contact process with weak to intermediate quenched disorder in its transmission rates is investigated via quasi-stationary Monte Carlo simulation. We address the contested questions of both the nature of dynamical scaling, conventional or activated, as well as of universality of critical exponents by employing a scaling analysis of ...
arxiv  

CE 560 Syllabus: Assessment and Treatment of Addictions [PDF]

open access: yes, 2021
This course addresses the principles of screening, assessment, diagnosis of substance use, induced, and co-occurring disorders in adults and adolescents, and treatment planning.
Moore, Mitch
core   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

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