Results 131 to 140 of about 1,329,001 (340)

Anabolic androgenic steroid abuse and their health impacts: A cross-sectional study among body builders in a city of Eastern India

International Journal of Preventive Medicine, 2019
Background: Anabolic-androgenic steroids (AASs), when taken in supraphysiologic doses, increase muscle strength and athletic performance. Evidence suggests that long-term use of AAS in supraphysiologic doses have adverse effects on health. Therefore, the
Subraham Pany, Sandeep Kumar Panigrahi, E Venkata Rao, Lipilekha Patnaik, Trilochan Sahu   +4 more
doaj   +1 more source

Efficacy of the Therapeutic Game "Trisquel" in the Treatment of Patients With Substance-Related Disorders Randomized Clinical Study. [PDF]

Front Psychiatry, 2022
Piñón-Blanco A, Vergara-Moragues E, Gutiérrez-Martínez O, Fernández-Palleiro P, Rodrigues S, Rodrigues-Amorím D, Lage-López MT, González-López A, Velasquez T, Amorim M, Lloves-Moratinos M, Viéitez-Fernández I, Sabio-Fernandez G, Graña-Torralba R, Vilar-Díaz V, Carrera-Machado I, Cancelo-Martinez J, Ferreira A, Cardoso S, Rivera-Baltanás T, Otero-Lamas F, Olivares JM, Spuch C.   +22 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Substance use disorders

, 2014
Substance use disorders involve alcohol and a range of other legal and illicit drugs, and are characterised by a preoccupation with or craving for the substance, a greater priority to substance use than other goals, and/or a difficulty controlling ...
Kavanagh, David, Gullo, Matthew, Connor, Jason   +2 more
core  

Prevalence rates of mental disorders in Chilean prisons [PDF]

, 2013
PMCID: PMC3718830This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Fritsch, R, Catalina Poblete, Poblete Catalina, Villagra Carolina, Alvarado, R, Kastner, Sinja, Rosemarie Fritsch, Priebe, Stefan, Mundt, AP, Priebe Stefan, Stefan Priebe, Kastner, S, Carolina Villagra, Fritsch Rosemarie, Mundt Adrian P., Villagra, C, Adrian P Mundt, Rubén Alvarado, Kastner Sinja, Fritsch Montero, Rosemarie, Sinja Kastner, Alvarado Rubén, Priebe, S, Villagra, Carolina, Poblete, C, Mundt, Adrian P., Alvarado Muñoz, Rubén, Poblete, Catalina   +27 more
core   +1 more source

A Survey on Substance Abuse Related Deaths Referred to Tehran's Legal Medicine Organization During 2007 and 2008 [PDF]

Acta Medica Iranica, 2011
Doubtlessly one of the major problems in Iran is drug abuse or substance abuse. The transmission of HIV/AIDS has made the problem so complicated that has created an urgent need for a campaign against this awful phenomenon.
Hamid Reza Daneshparvar, Fariba Sardari, Nasrin Esfahanizadeh   +2 more
doaj   +1 more source

Profiles of quality of outpatient care use, associated sociodemographic and clinical characteristics, and adverse outcomes among patients with substance-related disorders. [PDF]

Subst Abuse Treat Prev Policy, 2023
Fleury MJ, Cao Z, Grenier G, Huỳnh C.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Personality changes related to presence and treatment of substance use (disorders): a systematic review.

Heavy substance use (SU) and substance use disorders (SUD) have complex etiologies and often severe consequences. Certain personality traits have been associated with an increased risk for SU(D), but far less is known about personality changes related to
Baumgardt, Saskia, Asselmann, Eva, Juchem, Christina M, Bendau, Antonia, Reich, Nico J, Bandurski, Leonie C   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source