Results 191 to 200 of about 2,435,183 (357)

Social exclusion, integration barriers, and drug-related risk behaviours among immigrants in Europe: a systematic scoping review. [PDF]

Front Public Health
Sarpong JB, Acquah AN.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth. [PDF]

Nat Commun
Parr AC, Ojha A, Petrie DJ, Calabro FJ, Tervo-Clemmens B, Foran W, Fitzgerald D, Tapert SF, Nooner K, Thompson W, Goldston DB, Clark D, Luna B.   +12 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Substance use risk and controlled substances discussions in cancer care: Observations from audio-recorded patient-clinician encounters. [PDF]

Palliat Support Care
Yusufov M, Pollak KI, Poort H, Beaussant Y, Tarbi EC, Leiter RE, Tulsky JA.   +6 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patterns and trends of drug abuse in Summit and Stark Counties, Ohio : a report prepared for the Ohio Substance Abuse Monitoring (OSAM) Network [PDF]

Semiannual; Electronic coverage as of Sept. 26, 2006: June 1999/Jan. 2000-; Description based on: June 1999/Jan. 2000 issue; title from cover of PDF (viewed Sept.
Ohio Substance Abuse Monitoring Network.
core  

Binge alcohol and cannabis co-use associated with depression in Black men. [PDF]

Psychol Addict Behav
Mbaba M, Kearse TA, Massie J, Bowleg L.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity. [PDF]

Hum Brain Mapp
Flannery JS, Escalante ES, Ma R, Lindquist KA, Telzer EH.   +4 more
europepmc   +1 more source