Results 111 to 120 of about 50,728 (268)

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Abuse and misuse of antidepressants

Substance Abuse and Rehabilitation, 2014
Elizabeth A Evans, Maria A Sullivan Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA Background: Rates of prescription drug abuse have reached epidemic proportions.
Evans EA, Sullivan MA
doaj  

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

Small Science, EarlyView.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu, Jianxun Ding   +5 more
wiley   +1 more source

Role of acetaldehyde in alcohol addiction : current evidence and future perspectives [PDF]

, 2011
The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour.
Cacace, Silvana, Cannizzaro, Carla, Plescia, Fulvio   +2 more
core  

Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation

Small Structures, EarlyView.
Excessive inflammatory microglial cells in traumatic brain injury (TBI) site is a major driver of postinjury chronic neuroinflammation. A nanointegrative strategy is reported that enables efficient remodeling of TBI‐residing microglial cell fate specification through cooperative inhibition of NF‐κB/MAPK/TLR4 signaling and reactive oxygen species ...
Xuan Wang, Zhiqi Hu, Youbo Zhao, Yang Fei, Menghuan Li, Min Su, Zhong Luo, Rong Hu   +7 more
wiley   +1 more source

Remimazolam Preserves Oxygen Reserve and Improves Sedation Safety Compared to Propofol in Endoscopic Retrograde Cholangiopancreatography

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Remimazolam is a short‐acting benzodiazepine with less cardiorespiratory depression compared with propofol. The Oxygen Reserve Index (ORi) reflects oxygenation status in the mild hyperoxic range and can detect subtle respiratory depression induced by sedatives.
Jee Hoon Kim, Kyuho Lee, Sung Jin Lee, Galam Leem, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Namo Kim, Moon Jae Chung   +9 more
wiley   +1 more source

Surto de malária induzida entre usuários de drogas injetáveis

Revista de Saúde Pública
Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 ...
Luiz Carlos Barradas Barata, Maria Tereza M. Andriguetti, Marina Ruiz de Matos   +2 more
doaj  

Tissue engineering for tendon and ligament repair: Insights and advances

VIEW, EarlyView.
Tendon and ligament injuries are widespread diseases, leading to severe pain and a consequent reduced mobility. This phenomenon is mainly due to the limited ability to self‐healing of these tissues. Unfortunately, the currently available surgical and rehabilitative treatments suffer frequent complications and incomplete success.
Francesca Romano, Francesco Lopresti, Roberto Di Gesù, Vincenzo La Carrubba   +3 more
wiley   +1 more source

An Alternative Public Health Vision for a National Drug Strategy: Treatment Works [PDF]

, 1991
This article returns to a war waged virtually throughout this century--a war between the theories of punishment and rehabilitation in curtailing the drug epidemic. Today, the terms of the war are recast as supply-side policies based upon law enforcement;
Gostin, Lawrence O.
core   +1 more source