Results 141 to 150 of about 50,728 (268)

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

An Exploratory Study of Suboxone (Buprenorphine/ Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability [PDF]

, 2019
Suboxone films are U.S. Food and Drug Administration approved to treat opioid dependence. While the package insert states that films should not be cut, physicians often prescribe film fractions for treatment and tapering. There is no data to support this
Conn, Kelly, Corigliano, Anthony, DeAngelis, Michael J., Ferrara, Alexander S., Phillips, Elizabeth, Reindel, Kristin L., Zhao, Fang   +6 more
core   +1 more source

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

Cell Proliferation, EarlyView.
In this study, Bai et al. established a co‐culture system between neural organoids (NOs) and engineered heart tissues (EHTs) and demonstrated that NOs could secrete versican, which was absorbed by EHTs to ameliorate glucolipotoxicity. ABSTRACT Metabolic disorders could cause dysregulated glucose and lipid at the systemic level, but how inter‐tissue ...
Baochen Bai, Jiting Li, Ze Wang, Yuhan Yang, Jieqing He, Gonglie Chen, Yufan Zhang, Yan Qi, Zhongjun Wan, Lin Cai, Run Wang, Kai Wang, Dongyu Zhao, Jingzhong Zhang, Weihua Huang, Ronald X. Xu, Mingzhai Sun, Xiao Han, Yan Liu, Donghui Zhang, Wanying Zhu, Jian Liu, Yuxuan Guo   +22 more
wiley   +1 more source

Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Suzanne Nielsen, João Pedro Silva, Jermaine D. Jones, Alex Krotulski, Dilkushi Poovendran, Deusdedit Muzangizi, Gilles Forte, Jason White, Sandra D. Comer   +8 more
wiley   +1 more source

"The first shot": the context of first injection of illicit drugs, ongoing injecting practices, and hepatitis C infection in Rio de Janeiro, Brazil

Cadernos de Saúde Pública
The context of first drug injection and its association with ongoing injecting practices and HCV (hepatitis C virus) infection were investigated. Injection drug users (IDUs) (N = 606) were recruited in "drug scenes" (public places, bars) in Rio de ...
Maria de Lourdes Aguiar Oliveira, Mariana A. Hacker, Sabrina Alberti Nóbrega de Oliveira, Paulo Roberto Telles, Kycia Maria Rodrigues do Ó, Clara Fumiko Tachibana Yoshida, Francisco I. Bastos   +6 more
doaj  

Creating Safer Injecting Practices Through Community‐Led Harm Reduction: Lessons From People Who Use Steroids for the Alcohol and Other Drug Sector

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction Research on anabolic–androgenic steroid (AAS) use has addressed health outcomes, social dynamics, service access and risk management strategies. Yet little work has examined how these domains converge in injection practices, where community‐led knowledge and structural barriers shape harm reduction.
Timothy Piatkowski, Emma Kill, Geoff Davey, Monica J. Barratt, Jason Ferris, Suzanne Nielsen, Amy Peacock   +6 more
wiley   +1 more source

Urgent Need for Pairing Training and Education With Fentanyl Test Strip Distribution

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction Fentanyl test strips (FTS) are increasingly recommended for non‐heroin drugs to detect potential fentanyl adulteration. The aim of this study was to better understand how people are using FTS. Methods In simulation exercises between September and October 2023, 40 people who used drugs participated in a mock use of FTS on a ...
Megan K. Reed, Tracy Esteves Camacho, Kristin L. Rising, Rose Laurano, Danielle Albaciete, Stephen E. Lankenau   +5 more
wiley   +1 more source

Status quo and future developments in the diagnosis and treatment of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Andreas Recke
wiley   +1 more source

Prognostic factors and impact of management strategies for status epilepticus: The STEPPER study in the Emilia‐Romagna region, Italy

Epilepsia, Volume 66, Issue 3, Page 753-767, March 2025.
Abstract Objective The STEPPER (Status Epilepticus in Emilia‐Romagna) study aimed to investigate the clinical characteristics, prognostic factors, and treatment approaches of status epilepticus (SE) in adults of the Emilia‐Romagna region (ERR), Northern Italy.
Lidia Di Vito, Eleonora Matteo, Stefano Meletti, Corrado Zenesini, Giorgia Bernabè, Chiara Bomprezzi, Maria Chiara Casadio, Carlo Alberto Castioni, Edward Cesnik, Carlo Coniglio, Marco Currò‐Dossi, Patrizia De Massis, Elisa Fallica, Irene Florindo, Giada Giovannini, Maria Guarino, Elena Marchesi, Andrea Marudi, Elena Merli, Giulia Monti, Niccolò Orlandi, Elena Pasini, Daniela Passarelli, Rita Rinaldi, Romana Rizzi, Michele Romoli, Mario Santangelo, Valentina Tontini, Giulia Turchi, Mirco Volpini, Andrea Zini, Lucia Zinno, Roberto Michelucci, Luca Vignatelli, Paolo Tinuper, Francesca Bisulli, the STEPPER study group, Emanuele Saverio Cece, Fabio Nobili, Gabriele Ricci, Gloria Stoffella, Maria Tappatà, Stefania Testoni, Anna Zaniboni, Roberto D’Alessandro, Marco Zanello, Yerma Bartolini, Giovanni Bini, Maura Pugliatti, Francesca Ceccaroni, Chiara Leta, Claudia Giorgi, Edoardo Picetti, Alessandro Pignatti, Ilaria Naldi, Marco Russo, Anna Rita Guidi   +56 more
wiley   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source