Results 51 to 60 of about 50,728 (268)
Confronting the opioid crisis: Practical pain management and strategies: AOA 2018 critical issues symposium [PDF]
, 2019 The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management.
Hsu, Joseph R +4 more
core +1 more source
Decreased dopamine activity predicts relapse in methamphetamine abusers. [PDF]
, 2012 Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated.
Alia-Klein, N +11 more
core +1 more source
Advanced Science, EarlyView.Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen +3 more
wiley +1 more source
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures [PDF]
, 2019 Objective To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Boes, Julian +6 more
core +1 more source
Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Advanced Science, EarlyView.Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr. +20 more
wiley +1 more source
Harm Reduction Journal, 2021 Background Some people do not benefit from oral administration of opioid agonist treatment, and an intravenous (IV) formulation may be more suitable. Our objective was to evaluate the willingness of people who regularly inject sublingual buprenorphine to
Salim Mezaache +6 more
doaj +1 more source
Annals of Neurology, EarlyView.This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije +9 more
wiley +1 more source
HIV education in a Siberian prison colony for drug dependent males
International Journal for Equity in Health, 2004 Aim To evaluate the effectiveness of an HIV peer training program conducted in a colony for drug dependent male prisoners in Siberia, Russia. Method Questionnaires were used to collect data pre and post peer training sessions.
White Bethany, Bijl Murdo, Dolan Kate A
doaj +1 more source
WORKPLACE SUBSTANCE USE, THE RISK OF OCCUPATIONAL INJURY, AND TESTING [PDF]
, 2005 Over the past 20 years, the "workplace substance abuse prevention industry" has grown enormously in size and has become more sophisticated in its marketing approach. Drug testing alone has become a $6 billion industry.
Zimbardi, Guy
core
Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation
Annals of Neurology, EarlyView.Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko +9 more
wiley +1 more source