Results 141 to 150 of about 622,272 (313)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

The availability of LGBT-specific mental health and substance abuse treatment in the United States. [PDF]

Health Serv Res, 2020
Williams ND, Fish JN.
europepmc   +1 more source

Quality of life and its related factors in women with substance use disorders referring to substance abuse treatment centers. [PDF]

BMC Womens Health, 2021
Barati M, Bandehelahi K, Nopasandasil T, Jormand H, Keshavarzi A.   +4 more
europepmc   +1 more source

A Matter of Substance, December 2009. [PDF]

, 2009
A publication of the IDPH Division of Behavioral Health to find out what's happening with Substance Abuse Prevention and ...

core  

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Iowa Budget Report, Governor's Office of Drug Control Policy Budgets, 2018-2019 [PDF]

, 2017
The Office of the Drug Policy Coordinator, established in Chapter 80E of the Code of Iowa, directs the Governor's Office of Drug Control Policy (ODCP); coordinates and monitors all statewide counter-drug efforts, substance abuse treatment grants and ...

core  

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

The Effect of Psychiatric Clerkship on Fifth Year Medical Students’ Attitudes Toward Psychiatry and Their Intention to Pursue Psychiatry as a Career

Iranian Journal of Psychiatry, 2006
Objective: The purpose of this study was to examine whether attitudes toward psychiatry improved during psychiatric attachment as well as the relationship between attitudes to psychiatry and intention to pursue psychiatry as a career.
Yassaman Mottaghipour, Ali Reza Noroozi, Mehdi Samimi   +2 more
doaj  

Women's Barriers to Specialty Substance Abuse Treatment: A Qualitative Exploration of Racial/Ethnic Differences. [PDF]

J Immigr Minor Health, 2020
Pinedo M, Zemore S, Beltrán-Girón J, Gilbert P, Castro Y.   +4 more
europepmc   +1 more source

A peek behind the curtain: exploring coaching styles within the implementation and sustainment facilitation (ISF) strategy in the substance abuse treatment to HIV care study. [PDF]

Implement Sci Commun, 2021
Ford JH, Gilson AM, Maurer MA, Hoffman KA, Garner BR.   +4 more
europepmc   +1 more source