Results 31 to 40 of about 622,272 (313)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

ART adherence changes among patients in community substance use treatment: a preliminary analysis from MACH14

AIDS Research and Therapy, 2012
Background Opiate substitution treatment has been associated with better adherence to lifesaving antiretroviral medications, but the impact of other substance abuse treatment on adherence is unknown.
Rosen Marc I, Black Anne C, Arnsten Julia H, Simoni Jane M, Wagner Glann J, Goggin Kathleen, Remien Robert H, Golin Carol E, Wang Yan, Bangsberg David, Liu Honghu H   +10 more
doaj   +1 more source

Trends and correlated outcomes in population-level prescription opioid and transdermal fentanyl use in Israel

Israel Journal of Health Policy Research, 2023
Background In the last twenty years, there was a documented increase in prescription opioid procurement in Israel. However, there is still little evidence of the association between opioid procurement rates, health service utilisation in secondary care ...
Barak Shapira, Ronny Berkovitz, Ziona Haklai, Nehama Goldberger, Irena Lipshitz, Paola Rosca   +5 more
doaj   +1 more source

Prevalence of Substance Abuse in Patients with Schizophrenia [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Substance abuse is a common comorbidity in patients of Schizophrenia. Link between the use of substances and development of psychosis is demonstrated by high prevalence of substance abuse in schizophrenia.
Parisha Narayan Kelkar, Ganpat K Vankar, Kshirod K Mishra, Sally John, Ajinkya Sureshrao Ghogare   +4 more
doaj   +1 more source

Substance Abuse Treatment and Public Safety [PDF]

, 2008
The Substance Abuse Treatment and Public Safety brief found that the sooner substance abuse is treated, the bigger the long-term cost savings and increases in public safety.

core  

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Homelessness and Substance Abuse: Is Mandatory Treatment the Solution? [PDF]

, 1994
For the government to be successful in addressing homelessness, it must focus on the link between homelessness and substance abuse. In New York City and elsewhere, advocates are reluctant to publicize the connection between substance abuse and ...
Abbott, Melanie B.
core   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Component Analysis of the Illegal Handmade Pills and Capsules for Self-Medicating Substance Dependence in Tehran, Iran [PDF]

Addiction and Health, 2018
Background: To self-medicate substance dependence, many substance users consume herbal medicines delivered in herbal medicine shops which are prepared through non-standard methods using a variety of different materials.
Hamid Reza Khoddami-Vishteh, Hooman Narenjiha, Roya Noori, Azadeh Olyaei, Afsaneh Fard-Sanei, Monir Fekri, Ali Farhoudian   +6 more
doaj  

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source