Results 101 to 110 of about 226,603 (334)

Addressing negative attitudes, developing knowledge: the design and evaluation of a bespoke substance misuse module. [PDF]

open access: yes, 2017
Recent calls for the inclusion of substance misuse into social work curricula appear to have been met with a piecemeal and rather sporadic approach from many Higher Education establishments.
Goddard, Zuzia   +3 more
core   +1 more source

Improving family functioning and child outcome in methadone maintained families: the parents under pressure programme

open access: yes, 2003
t Societal responses to the existence of substance misuse fluctuate between harm minimisation and prohibition. Both approaches are predominantly downstream reactions to substance misuse that focus on the supply of harmful substances and the containment ...
Dawe, Sharon   +3 more
core   +1 more source

Substance misuse and the social work ethos. [PDF]

open access: yes, 1996
The contribution which social work can make to the resolution or minimization of problems stemming from the use of alcohol and drugs is best understood in the context of the profession's ethos.
Butler, Shane
core   +1 more source

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

open access: yesAdvanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu   +7 more
wiley   +1 more source

Identifying Early Warning Signs: Addressing Youth Substance Use [PDF]

open access: yes, 2015
Of high school students 35 percent indicate they are current drinkers, 20 percent are binge drinkers, and 24 percent use marijuana. By the time they are seniors more than 20 percent will have used a prescription drug for a nonmedical purpose.

core  

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

open access: yesAdvanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao   +12 more
wiley   +1 more source

Posttraumatic Stress Disorder and Substance Misuse Among Black Emerging Adults: The Influence of Social Support

open access: green, 2021
Miranda E. Reyes   +4 more
openalex   +2 more sources

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

open access: yesAdvanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye   +18 more
wiley   +1 more source

College Adjustment Adds Incremental Validity in Assessing Substance Misuse in College Students

open access: yesJournal of College Orientation, Transition, and Retention
This study examined college adjustment aspects that are associated with substance misuse, complimenting demographic and individual difference factors that have successfully predicted problematic use in past studies.
Virginia Wickline   +6 more
doaj   +1 more source

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