Results 111 to 120 of about 802,297 (310)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Changes in harm reduction service providers professional quality of life during dual public health emergencies in Canada

Harm Reduction Journal
Background Harm reduction (HR) is a critical response to the pronounced toxicity deaths being experienced in Canada. HR providers report many benefits of their jobs, but also encounter chronic stress from structural inequities and exposure to trauma and ...
Sheena Taha, Samantha King, Sara Atif, Eliza Bate   +3 more
doaj   +1 more source

Outcome of psychological treatment of patients with substance use disorders in routine care

, 2017
Background: More knowledge is needed about outcome of treatments in routine care for patients with substance use disorders (SUDs). These patients often suffer from psychological distress in addition to SUDs.
Gidhagen, Ylva,, Holmqvist, Rolf,, Philips, Björn,   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Prevention of Substance Use Disorders in Latino/Latina American Communities

, 2023
This chapter focuses on substance use in adolescent Latino/LatinaAmericans, with an underlying focus on social determinants of health and how they may exacerbate substance use among this population.
Prado, Guillermo, Lozano, Alyssa, Estrada, Yannine, Fernandez, Alejandra   +3 more
core   +1 more source

Chapter 2. General Theoretical Perspectives of Narrative Analysis of Substance Use-Related Dependency

, 2013
This chapter provides a short introduction to, and an overview for, using narrative analysis in the understanding of the use and misuse of alcohol and drugs. Important theoretical and methodological dimensions are discussed.
Sjöblom, Yvonne,, Lilja, John, von Braun, Thérèse,, Sam Larsson, Yvonne Sjöblom, Larsson, Sam,, Lilja, John,, John Lilja, Therese von Braun   +8 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A multidimensional model for narrative analysis of substance use-related dependency

, 2013
This chapter examines the possibilities and limitations of using a narrative method as a framework within a multidimensional model for exploring and analyzing the use and misuse of alcohol and drugs.
Lilja, John, von Braun, Thérèse,, Larsson, Sam,, Lilja, John,   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source