Results 151 to 160 of about 53,729,253 (423)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Low-cost spectrogram based counterfeit medicine detection [PDF]

open access: yesarXiv, 2019
Contaminated substances such as counterfeit medication and food contami-nated with pesticide residue is a pandemic of utmost urgency. Spectroscopy and chromatography methods are often used but are expensive and complex and as such a need exists for a device that can be easily operated in developing commu-nities. We present a hacked visible spectrometer
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Women and substance use disorders

open access: yesMens Sana Monographs, 2009
Substance use disorders belong to the class of externalizing behaviours that are generally more common among men than women. Those women who do have substance disorders therefore deviate more from the norms of society compared with men, tend to live in an environment characterized by high risk of violence and other forms of abuse, and tend to be ...
Hecksher, Dorte, Hesse, Morten
openaire   +5 more sources

Substance use and associated factors among Debre Berhan University students, Central Ethiopia

open access: yesSubstance Abuse Treatment, Prevention, and Policy, 2018
BackgroundBeing a global burden of youths, substances use is unhealthy behavior that exposes youths to health and social problems. Knowledge of the prevalence and predictors of substance use behavior among university students is important for designing ...
T. Gebremariam   +2 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Housing and overdose: an opportunity for the scale-up of overdose prevention interventions?

open access: yesHarm Reduction Journal, 2017
Background North America is currently experiencing an overdose epidemic due to a significant increase of fentanyl-adulterated opioids and related analogs.
Geoff Bardwell   +3 more
doaj   +1 more source

Substance Use Disorders

open access: yesDeckerMed Medical Cannabis, 2018
There is a consistent body of evidence showing that substance abuse and dependence can worsen preexisting medical conditions, can temporarily mimic medical and psychiatric disorders, and can themselves cause medical problems, including life-threatening overdose.
openaire   +1 more source

Home - About - Disclaimer - Privacy