Results 261 to 270 of about 2,088,860 (358)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Kairomonal Activity of White-Tailed Deer Metatarsal Gland Substances: A More Sensitive Behavioral Bioassay Using Ixodes Scapularis (Acari: Ixodidae)

, 1998
J. F. Carroll
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Involuntary Treatment for Severe Substance Use Disorders - Issues, Evidence and Considerations for its Use. [PDF]

Can J Psychiatry
Fischer B, Hall W, Jutras-Aswad D, Le Foll B.   +3 more
europepmc   +1 more source

Validity of psychiatric diagnoses in patients with substance use disorders: Is the interview more important than the interviewer?

, 1995
Henry R. Kranzler, Ronald M. Kadden, Joseph A. Burleson, Thomas F. Babor, Andrew Apter, Bruce J. Rounsaville   +5 more
openalex   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Suicidal Ideation and Substance Use Among Middle and High School Students in Morocco. [PDF]

Healthcare (Basel)
Baslam A, Azraida H, Boussaa S, Chait A.
europepmc   +1 more source

Collection of chemical substances in water using a thermally reversible polymer.

, 1997
Toshihisa Ohyama, Kensuke Arai, Tamaki NAKAGAWA, Chiyo Matsubara, Kiyoko Takamura   +4 more
openalex   +2 more sources

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Substance Use Disorder [PDF]

, 2019
O'Horo, John C
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