Results 261 to 270 of about 54,698,481 (374)
Research Review: What have we learned about adolescent substance use?
K. Gray, L. Squeglia
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tobacco-Related Knowledge Among Employees at Substance Use Treatment and Medical Healthcare Centers Serving Rural and Medically Underserved Patients with Substance Use Disorders in Texas, USA. [PDF]
Feyisetan JA +8 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The CB1 receptor: linking impulsivity and substance use disorder. [PDF]
Amancio-Belmont O +2 more
europepmc +1 more source
A family history of alcoholism relates to alexithymia in substance use disorder patients
Hein A. de Haan +6 more
openalex +2 more sources
TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source

