Results 261 to 270 of about 54,698,481 (374)

Research Review: What have we learned about adolescent substance use?

open access: yesJournal of Child Psychology and Psychiatry and Allied Disciplines, 2018
K. Gray, L. Squeglia
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Correction: Is fentanyl in everything? Examining the unexpected occurrence of illicit opioids in British Columbia’s drug supply

open access: yesHarm Reduction Journal
Bruce Wallace   +12 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

The CB1 receptor: linking impulsivity and substance use disorder. [PDF]

open access: yesFront Neurosci
Amancio-Belmont O   +2 more
europepmc   +1 more source

A family history of alcoholism relates to alexithymia in substance use disorder patients

open access: bronze, 2013
Hein A. de Haan   +6 more
openalex   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

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