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Genetics of Substance Use Disorders
Child and Adolescent Psychiatric Clinics of North America, 2016Substance abuse disorders have a strong genetic component. Genetic risk factors associated with alcohol abuse include common variants in genes coding for alcohol-metabolizing enzymes and gamma-aminobutyric acid A receptors. Functional missense mutations in ADH1B and ALDH2 are protective against alcohol dependence.
Cassie, Yu, Jon, McClellan
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Substance Use Disorders Refresh: Nonopioid Substance Use Disorders
Psychiatric Services, 2023Nan, Zhao +2 more
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Pharmacotherapy for Substance Use Disorders
Medical Clinics of North America, 2016This article reviews the current pharmacotherapy options available for the treatment of patients with substance use disorders. In the United States there are medications available to treat tobacco use disorders (nicotine replacement, bupropion, and varenicline), alcohol use disorders (naltrexone and acamprosate), and opioid use disorders (methadone and
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Substance Use Disorders and ADHD
CNS Spectrums, 2009In examining the challenges in treating comorbid attention-deficit/hyperactivity disorder (ADHD) and substance use disorder (SUD), there are a number of issues regarding misinformation and misconception that exist for clinicians. Like other ADHD comorbidities, there is a lack of screening, particularly among adult clinical populations who have the ...
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The patient with substance use disorder
Current Opinion in Anaesthesiology, 2019The purpose of this review is to describe the anesthesiologist's perioperative challenges when caring for the patient with substance use disorder and, in particular, opioid use disorder.With the introduction of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, psychiatric literature recently changed the criteria for defining ...
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American Journal of Psychiatry, 1996
The authors examined the association between conduct disorder and substance use disorders in adolescent inpatients.Structured diagnostic interviews were given to 165 adolescent inpatients to assess the presence of DSM-III-R axis I disorders and personality disorders from axis II. Patients with conduct disorder (N = 25), substance use disorders (N = 24),
C M, Grilo +4 more
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The authors examined the association between conduct disorder and substance use disorders in adolescent inpatients.Structured diagnostic interviews were given to 165 adolescent inpatients to assess the presence of DSM-III-R axis I disorders and personality disorders from axis II. Patients with conduct disorder (N = 25), substance use disorders (N = 24),
C M, Grilo +4 more
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Comorbidity of Mental Disorders and Substance Use Disorders
European Addiction Research, 2009Recent major epidemiological surveys in general population samples throughout the world have demonstrated that substance use disorders are among the most frequent forms of mental disorders in the community, and are also frequently associated with other forms of mental disorders.
Wittchen, H., Perkonigg, A., Reed, V.
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Neuroglia in substance use disorders
Substance use disorders (SUD) remain a major public health concern in which individuals are unable to control their use of substances despite significant harm and negative consequences. Drugs of abuse dysregulate major brain and behavioral functions. Glial cells, primarily microglia and astrocytes, play a crucial role in these drug-induced molecular ...Emily M, Castro +2 more
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The Genetics of Substance Use and Substance Use Disorders
2009The abuse of licit and illicit drugs constitutes one of the leading public health problems in the world. There are tens of millions of alcohol or drug abusers and more than a billion smokers in the world (WHO, 2002). Each year, substance abuse results in the loss of tens of millions of dollars due to health-care costs and lost productivity (Cartwright,
Danielle M. Dick +2 more
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