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Substantia Nigra and Parkinsonism

Archives of Neurology, 1964
The opinion that parkinsonism is caused by damage of the substantia nigra was advanced by Brissaud 1 on the basis of the findings in a case of Charcot's studied by Bechet 2 and Blocq and Marinesco. 3 In a series of 54 autopsies Tretiakoff 4 found the substantia nigra degenerated in 16 categories of neurologic disorder including three cases of ...
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Innervation of the substantia nigra

Cell and Tissue Research, 2004
This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine released from the somato-dendritic compartment of dopamine neurons and endocannabinoids released from dopamine ...
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Neuropathology of the Substantia nigra

European Neurology, 1991
Neuronal subpopulations of the substantia nigra pars compacta can be separated into two functionally distinct nigrostriatal projections, the ventral tier which is poorly melanised, and the dorsal tier which is well melanised. In Parkinson's disease, juvenile-onset parkinsonism with dystonia and striatonigral degeneration the ventral tier is more ...
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Dopamine release in substantia nigra?

Nature, 1976
IN addition to the axons which project to the nucleus caudatus1,2, the dopamine (DA)-containing perikarya of the substantia nigra have extensive dendritic processes. These dendrites, observed after Golgi staining3–5 and by electron microscopy3,4, contain relatively large amounts of DA—revealed by histofluorescence6—and vesicle–like structures4.
KORF, J, ZIELEMAN, M, WESTERINK, BHC
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The neuromelanin of the human substantia nigra

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991
The pigment of the human substantia nigra was isolated after extraction of lipids and proteins with 2% sodium cholate in 30% ethanol followed by 2% sodium dodecyl sulfate in 10% glycerol. The pigment was hydrolysed with HI or degraded by treatment with KMNO4 and the samples were examined for compounds known to derive from pheomelanin (4-amino-3 ...
R, Carstam   +4 more
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Diagnostic evaluation of the substantia nigra

Neuropathology and Applied Neurobiology, 1996
An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique
D A, McRitchie   +2 more
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Cytoarchitecture of the substantia nigra in the rat

American Journal of Anatomy, 1970
AbstractMidbrains of ten young adult rats were sectioned serially in three planes to study the detailed cytoarchitecture of the substantia nigra. These neurons measure 8 to 17 μ in diameter. In comparison, the largest neurons in the midbrain measure 20 to 40 μ; hence, neurons are designated according to size as follows: those measuring 18 to 40 μ ...
J, Hanaway, J A, McConnell, M G, Netsky
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