Results 91 to 100 of about 1,609,846 (283)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Women Parliamentary Representation in Africa and Growth of Women Businesses

Acta Universitatis Danubius: Administratio, 2023
The connection between women representation in parliament and the extent of substantive representation of women’s interest remains ambiguous. Objective: this paper aims to understand if women representation in African parliament catalyses growth in women
Collins C Ngwakwe, Mamoloko Rachidi
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Contained or represented? The varied consequences of reserved seats for emigrants in the legislatures of Ecuador and Colombia

Comparative Migration Studies, 2018
The legislatures of Colombia and Ecuador have reserved seats for their non-resident citizens (emigrants). This paper analyses the relationship between the formal, descriptive, and substantive dimensions of emigrant representation in their homeland ...
Pau Palop-García
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Women's contested politics of presence : learning from the experiences of Pakistani women parliamentarians [PDF]

This study provides a case study of women’s political representation in the National Parliament of Pakistan, where a particular form of the quota approach has been adapted in a highly gendered political context.
Syed, Shaheen Ashraf Shah
core  

Analyzing Women's Substantive Representation: from critical mass to critical actors

, 2009
This article makes a case for rethinking traditional approaches to the study of legislative behaviour on behalf of women by asking (1) not when women make a difference, but how the substantive representation of women occurs; and (2) not what ‘women’ do ...
Childs, SL, Krook, ML
core   +1 more source

Mechanothermodynamic System as the New Subject of Research

Механика машин, механизмов и материалов, 2011
It is shown that representation about mechanothermodynamic system inevitably conducts to working out of substantive provisions of new physical discipline - mechanothermodynamic.
M.S. Vysotski, P.A. Vityaz , L.A. Sosnovskiy   +2 more
doaj  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source