Results 141 to 150 of about 13,866 (306)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Motherhood Penalty—Beyond Bias? From Stereotypes to Substitutability Structures [PDF]
Mothers continue to experience lower wages and slower career progression than fathers. Are mothers penalized due to prejudice or due to the costs of family-friendly work conditions? Our review of experimental studies on motherhood bias reveals a paradox:
Mangset, Marte, Halrynjo, Sigtona
core +1 more source
Sustainable supply of critical materials for water electrolysers and fuel cells
Communications Earth & EnvironmentWater electrolysers and fuel cells are key technologies for global energy transition. Many materials used in them are critical, facing supply challenges.
Dengye Xun +8 more
doaj +1 more source
Who Bears Green Costs in Competitive Supply Chains
MathematicsGreen investment is increasingly important in sustainable supply chain management, but it remains unclear whether the associated costs should be borne by manufacturers or retailers in competitive markets.
Yudong Li, Yan Chen
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Giffen Behaviour and Asymmetric Substitutability
, 2010 Let a consumer consume two goods, and let good 1 be a Giffen good. Then a wellknown necessary condition for such behaviour is that good 1 is an inferior good.
De Jaegher, Kris
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Science and Technology for Energy TransitionTextile manufacturing plays an imperative role in the economic development of several countries. Among the world’s top ten textile exporters, China reported positive growth.
Li Linying, Raza Muhammad Yousaf
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source