Results 201 to 210 of about 10,094 (307)

Development of Drug-Device Combination Products and Generic Substitution in the United States. [PDF]

Innov Pharm
Srivastava I, Lee Y, Feibus KB, Bielski ER, Sterrett L, Harris D, Luke MC.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The genetic lottery goes to school: Better schools compensate for the effects of students' genetic differences. [PDF]

Proc Natl Acad Sci U S A
Cheesman R, Borgen N, Sandsør AMJ, Hufe P.   +3 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Exploring the associations between features from multi-parametric MR images in Glioblastoma using radiomics. [PDF]

BMC Med Imaging
Xu L, Zhao W, Guo R, Huang X.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

IMPLICIT PRICE AND DEMAND IN OLIGOPOLISTIC COMPETITION: AN APPLICATION TO THE U.S. TROUT MARKET

This study provides an example of how implicit price and demand models can be developed and used for empirical analysis. In particular, empirical application of these models can quantify the impact of implicit economic variables representing preference ...
Lee, Young-Jae, Kennedy, P. Lynn, Hilbun, Brian M.   +2 more
core  

Ecology and the evolution of cooperation by partner choice and reciprocity. [PDF]

Sci Rep
Fuentes M.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of Replacing Fish Meal With Plant Protein Sources in Diets With or Without Jack Mackerel Meal Inclusion on Growth Performance of Red Sea Bream (<i>Pagrus major</i>). [PDF]

Aquac Nutr
Sim YJ, Cho SH, Kwon TW, Shin HC, Na HM, Kwon YW, Shin SW, Lee SH, Lee KW, Choi J.   +9 more
europepmc   +1 more source