Results 141 to 150 of about 896,089 (265)

Machine learning framework for cost effective deep mutational scanning through targeted substitution profiling. [PDF]

BMC Bioinformatics
Morgan E, Govender S, Singh P, Goodfellow I, Graham SC, Bishop NT, Bishop ÖT.   +6 more
europepmc   +1 more source

The Intertemporal-Substitution Hypothesis is Alive and Well (But Hiding in the Data)

According to the intertemporal-substitution hypothesis, which underlies the typical empirical real business cycle model, cyclical fluctuations in employment and hours of work are optimizing labor-supply responses to short-run aggregate demand shifts.
Jean Kimmel
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

SUBSTITUTION BETWEEN U.S. AND CANADIAN WHEAT BY CLASS

The importation of hard red winter and durum wheat from Canada has been a source of contention among U.S. wheat growers, due to the likeness between domestic and imported Canadian wheat. It has also been investigated as a source of material injury to the
Koo, Won W., Mulik, Kranti
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Coal gangue substitution reshapes soil-plant interactions to regulate vegetable growth: implications for recycling industrial waste in sustainable agriculture. [PDF]

BMC Plant Biol
Hou S, Zhang R, Zhang C, Wang H, Li X, Wang H, Wang X.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Structure, Electrochemistry, and Phase Evolution of Al-Substituted Na_2/3[Ni_1/3‑yMn_2/3‑zAl _{<i>y</i>+<i>z</i>} ]O₂ as a Sodium-Ion Battery Cathode Material. [PDF]

Chem Mater
Pacileo AT, Deegan P, Liu H.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The dual use dilemma: Is it better to have tried and failed to quit smoking with e-cigarettes or to have never tried e-cigarettes at all? [PDF]

Prev Med
Klemperer EM, Wiley RC, Carpenter MJ.
europepmc   +1 more source