Results 41 to 50 of about 158,025 (288)

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 [PDF]

, 2014
The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear.
Billen, Johan, Braeckman, Bart, De Haes, Wouter, Depuydt, Geert, Frooninckx, Lotte, Schoofs, Liliane, Smolders, Arne, Temmerman, Liesbet, Van Assche, Roel   +8 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Cell Reports, 2018
Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons.
Katharina Timper, Lars Paeger, Carmen Sánchez-Lasheras, Luis Varela, Alexander Jais, Hendrik Nolte, Merly C. Vogt, A. Christine Hausen, Christian Heilinger, Nadine Evers, J. Andrew Pospisilik, Josef M. Penninger, Eric B. Taylor, Tamas L. Horvath, Peter Kloppenburg, Jens Claus Brüning   +15 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Activitatea respiraţiei din comunităţile microbiene ale cernoziomului arat din Republica Moldova

Agricultural Science, 2020
The respiration activity of the microbial communities in the plowed chernozem was evaluated in fractions of the values of basal respiration (BR), substrate-induced respiration (SIR), as well as of specific respiration (qCO2), in relation to the soil of ...
Nina FRUNZE
doaj  

Extra-matrix Mg\u3csup\u3e2+\u3c/sup\u3e Limits Ca\u3csup\u3e2+\u3c/sup\u3e Uptake and Modulates Ca\u3csup\u3e2+\u3c/sup\u3e Uptake-independent Respiration and Redox State in Cardiac Isolated Mitochondria [PDF]

, 2013
Cardiac mitochondrial matrix (m) free Ca2+ ([Ca2+]m) increases primarily by Ca2+ uptake through the Ca2+ uniporter (CU). Ca2+ uptake via the CU is attenuated by extra-matrix (e) Mg2+ ([Mg2+]e).
Blomeyer, Christoph A., Boelens, Age D., Camara, Amadou K.S., Dash, Ranjan K., Pradhan, Ranjan K., Stowe, David F.   +5 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Differential Effects of Buffer pH On Ca\u3csup\u3e2+\u3c/sup\u3e-Induced ROS Emission with Inhibited Mitochondrial Complexes I and III [PDF]

, 2015
Excessive mitochondrial reactive oxygen species (ROS) emission is a critical component in the etiology of ischemic injury. Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ...
Aldakkak, Mohammed, Camara, Amadou K. S., Lindsay, Daniel P., Lubbe, Ryan, Stowe, David F.   +4 more
core   +1 more source

Studies of the physiology, pharmacology, and biochemistry of the auxins [PDF]

, 1952
Several excellent reviews of auxin matters have appeared during the past few years dealing broadly with the subject as a whole, such as the Wisconsin Symposium on Plant Growth Substances whleh is referred to repeatedly below, as well as reviews of more ...
Bandurski­, Robert S., Bonner, James
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source