Results 71 to 80 of about 159,459 (288)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Characterization of Shewanella oneidensis MtrC: a cell-surface decaheme cytochrome involved in respiratory electron transport to extracellular electron acceptors [PDF]

, 2007
MtrC is a decaheme c-type cytochrome associated with the outer cell membrane of Fe(III)-respiring species of the Shewanella genus. It is proposed to play a role in anaerobic respiration by mediating electron transfer to extracellular mineral oxides that ...
AI Tsapin, AJ Bard, AS Beliaev, AS Beliaev, BH Kim, Brian N. Jepson, C Myers, C Myers, C Schwalb, CR Myers, CR Myers, CR Myers, CR Myers, D Leys, David J. Richardson, DJ Richardson, E Berry, EHJ Gordon, FA Walker, GR Moore, HJ Kim, I Gautier-Luneau, J Hirst, JF Heidelberg, Jim Fredrickson, JK Fredrickson, JM Myers, JM Myers, JM Philo, John Zachara, Julea N. Butt, K Venkateswaren, KE Pitts, KH Nealson, KH Nealson, Kurnikov, L Shi, L Shi, Liang Shi, LJ Anderson, MG Almeida, MP Hendrich, MP Hendrich, PL Dutton, PS Dobbin, R Aasa, Robert S. Hartshorne, Sarah J. Field, SJ Field, T Horan, TA Clarke, Tom A. Clarke, VA Bamford   +52 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling

Nature Communications, 2023
Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin, Corentin Largeau, Sandrine Masscheleyn, Mathilde S. Piel, Daniel Calderón-Mora, Frédéric Bouillaud, Jérôme Hénin, Bruno Miroux   +7 more
doaj   +1 more source

Organic residues - a resource for arable soils [PDF]

, 2005
An increased recirculation of urban organic residues to arable soils has several environmental benefits, but there is a need for reliable test systems to ensure that soil quality is maintained.
Odlare, Monica
core  

Nutrient availability affects carbon turnover and microbial physiology differently in topsoil and subsoil under a temperate grassland [PDF]

, 2018
Increasing subsoil organic carbon inputs could potentially mitigate climate change by sequestering atmospheric CO2. Yet, microbial turnover and stabilization of labile carbon in subsoils are regulated by complex mechanisms including the availability of ...
Elsgaard, Lars, Jensen, Johannes L., Liang, Zhi, Olesen, Jørgen E.   +3 more
core   +1 more source

Copper‐based Materials for Photo and Electrocatalytic Process: Advancing Renewable Energy and Environmental Applications

Advanced Functional Materials, EarlyView.
Cu‐based catalysts as a cornerstone in advancing sustainable energy technologies are fully reviewed in this manuscript, highlighting their potential in photo‐ and electrocatalysis. It includes metallic copper, copper oxides, copper sulfides, copper halide perovskites, copper‐based metal–organic frameworks (MOFs), and covalent organic frameworks (COFs),
Jéssica C. de Almeida, Yanjie Wang, Thais A. Rodrigues, Paulo H. H. Nunes, Vagner R. de Mendonça, Paulo H. E. Falsetti, Leticia V. Savazi, Tao He, Alexandra V. Bardakova, Aida V. Rudakova, Jie Tian, Alexei V. Emeline, Osmando F. Lopes, Antonio Otavio T. Patrocínio, Jia Hong Pan, Caue Ribeiro, Detlef W. Bahnemann   +16 more
wiley   +1 more source

Fluoride Increases Superoxide Production and Impairs the Respiratory Chain in ROS 17/2.8 Osteoblastic Cells [PDF]

, 2014
It is known that fluoride produces oxidative stress. Inflammation in bone tissue and an impairment of the respiratory chain of liver have been described in treatments with fluoride. Whether the impairment of the respiratory chain and oxidative stress are
Fina, Brenda, Lombarte, Mercedes, Rigalli, Alfredo, Rigalli, Alfredo   +3 more
core   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Miniature Nanomesh Mechano‐Acoustic Sensor with Wide Linear Dynamic Range, Broad Bandwidth, and Flat Frequency Response

Advanced Functional Materials, EarlyView.
A miniaturized mechano‐acoustic sensor is developed using an electrospun PVDF nanomesh as the diaphragm in a capacitive sensor structure. Unlike conventional nanomesh‐based sensors, it achieves high linear sensitivity, a broad and flat frequency response, and a compact form factor.
Jeng‐Hun Lee, Kang Hyuk Cho, Seojin Yun, Siyoung Lee, Woongji Kim, Yunsik Kim, Wonkyu Moon, Yoonyoung Chung, Kilwon Cho   +8 more
wiley   +1 more source