Results 111 to 120 of about 3,794,549 (326)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Acta Agrobotanica, 2013 Two experiments were conducted, in which the granulated rockwool 'Grodan', utilised rockwool 'Flormin', used before as slabs and remained after 2-year carnation culture (UR) - shredded and steamed and two kinds of insulation rockwool of domestic ...
Zbigniew Strojny
doaj +1 more source
Suppression of the "notch effect” in microwave surface resistance in YBa2Cu3O7 films on MgO (100) substrate by deposition of ultra-thin SrTiO3 seed layers [PDF]
, 1999 J. P. Contour +5 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Wide bandgap and ultra-wide bandgap semiconductors
Fundamental Research, 2021 Yue Hao, Fengyi Jiang
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Back Cover: Selective placement of quantum dots on nanoscale areas of metal-free substrates (Phys. Status Solidi RRL 8/2014) [PDF]
, 2014 Isabelle Staude +7 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source