Results 101 to 110 of about 2,216,866 (310)
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases
Biotechnology for Biofuels and BioproductsBackground Oxidative enzymes targeting lignocellulosic substrates are presently classified into various auxiliary activity (AA) families within the carbohydrate-active enzyme (CAZy) database.
Hongbo Zhao +9 more
doaj +1 more source
Substrate Specificity and Enzymatic Characteristics of Three Rutinosidases
Shipin gongye ke-jiQuercetin, naringenin, and hesperetin are the hydrolysis products of rutinoside flavonoids, known for their multiple biological activities and potential applications.
Fengwei XIAO +4 more
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Nucleotide Triphosphate Substrate Specificity of DrGK.
, 2014 Nucleotide Triphosphate Substrate Specificity of DrGK.
Roman Gangl (529009) +2 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
A single amino acid mutation alters substrate specificity towards
Biochemistry and Biophysics ReportsStructure-based mutagenesis was performed to modify the substrate specificity of bacterial l -galactose dehydrogenase from Luteolibacter sp. strain LG18, which also exhibits intrinsic l -glucose dehydrogenase activity.
Nana Obara +8 more
doaj +1 more source
Inflammatory caspase substrate specificities
mBioABSTRACT Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation. Extensive efforts have been made to identify caspase substrates and to determine factors that dictate ...
Patrick M. Exconde +4 more
openaire +3 more sources
The Substrate and Anomeric Specificity of Fructokinase
Journal of Biological Chemistry, 1973 Abstract Fructokinase from beef liver is shown to be specific for the β-furanose anomer of d-fructose (and the α anomer of l-sorbose) by showing that certain 2,5-anhydroalditols are substrates, while other 2,5-anhydro compounds, 2,6-anhydro-d-mannitol, and 2,6-anhydro-d-glucitol are not.
F M, Raushel, W W, Cleland
openaire +2 more sources
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source