Results 161 to 170 of about 8,404 (278)

Transformer-based graphs for drug-drug interaction with chemical knowledge embedding. [PDF]

Brief Bioinform
Zhang J, Zhang X, Dai Y, Shao X, Fan X.
europepmc   +1 more source

Practical Application Of A Selection Criteria For Constructing The Superset Of Residual Flexibility Modes Used In Modal Synthesis Method

, 2015
The work presents the practical application of a criteria for selection of the normal modes of substructures with the purpose of building the superset of a residual flexibility model.
Araujo C.A., Kurka P.R.G.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Higher Dimensionality in the Mg-Co-B System: Synthesis and Structure of Incommensurate Composite Mg_1+εCo₄B₄. [PDF]

J Am Chem Soc
Oftedahl P, Bhaskar G, Parvez NJ, Zhang Z, Sun Y, Xiao JQ, Proffen T, Lebedev OI, Zaikina JV.   +8 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Development of QSAR Models and Web Applications for Predicting hDHFR Inhibitor Bioactivity Using Machine Learning. [PDF]

Molecules
Maattallaoui I, Sakho M, Maatallaoui A, Barrajón-Catalán E, Aouad NE.   +4 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

ChemBang: Expanding the Chemical Space Around Small Molecules. [PDF]

Mol Inform
Montes-Grajales D, Menestrina L, Garcia-Serna R, Mestres J.   +3 more
europepmc   +1 more source

Model Development and Stability Analysis for a Turbocharger Rotor System under Multi-Field Coupled Forces

Automotive turbochargers have been widely applied in vehicles in order to increase the power output of internal combustion engines by increasing the air to fuel ratio entering the piston cylinders.
Zhang, Hao
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source