Results 181 to 190 of about 8,404 (278)

Discovery of AKT1 Inhibitors for Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease Using QSAR-Guided Virtual Screening and Gaussian Accelerated Molecular Dynamics. [PDF]

ACS Omega
Cao K, Wang R, Ou D, Wu S, Chen Y, Li L, Liu X.   +6 more
europepmc   +1 more source

Analysis of structure vibration by substructure synthesis method.

Turbomachinery, 1984
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas. [PDF]

Sci Rep
Manjón JV, Morell-Ortega S, Ruiz-Perez M, Mansencal B, Bot EL, Gadea M, Lanuza E, Catheline G, Tourdias T, Planche V, Giraud R, Rivière D, Mangin JF, Labra-Avila N, Vivo-Hernando R, Rubio G, Aparici-Robles F, de la Iglesia-Vaya M, Coupé P.   +18 more
europepmc   +1 more source

Analysis of Vibration by Substructure Synthesis Method : Part.1 Basic Approach

Bulletin of JSME, 1983
NAGAMATSU, Akio, NAKAO, Akihiro, IWAMOTO, Toshitaka, NAGAIKE, Masaru   +3 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Machine Learning-Enabled Parallel Prediction and Co-Design of Polyimides for Tailored Glass Transition, Dielectric, and Bandgap Properties. [PDF]

ACS Omega
Liang B, Huo W, Wu X, Zheng R.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Population Genetic Structure, Historical Effective Population Size, and Dairy Trait Selection Signatures in Chinese Red Steppe and Holstein Cattle. [PDF]

Animals (Basel)
Niu P, Li X, Wang X, Qu H, Chen H, Huang F, Hu K, Fang D, Gao Q.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source